Introduction：Basic information about CAS 2709-56-0|Flupentixol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Flupentixol |
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| CAS Number | 2709-56-0 | Molecular Weight | 434.51800 |
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| Density | 1.306g/cm3 | Boiling Point | 554.7ºC at 760mmHg |
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| Molecular Formula | C23H25F3N2OS | Melting Point | / |
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| MSDS | / | Flash Point | 289.3ºC |
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Names
| Name | flupenthixol |
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| Synonym | More Synonyms |
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Flupentixol BiologicalActivity
| Description | Flupentixol is a high potency thioxanthene with D1 and D2 dopamine receptor antagonism. Flupentixol is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders[1][2]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
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| Target | D1 Receptor D2 Receptor |
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| References | [1]. Yonar D, et al. Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol. Chem Phys Lipids. 2016 Jun;198:61-71. [2]. Ruhrmann S, et al. Efficacy of flupentixol and risperidone in chronic schizophrenia with predominantly negative symptoms. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1012-22. |
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Chemical & Physical Properties
| Density | 1.306g/cm3 |
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| Boiling Point | 554.7ºC at 760mmHg |
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| Molecular Formula | C23H25F3N2OS |
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| Molecular Weight | 434.51800 |
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| Flash Point | 289.3ºC |
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| Exact Mass | 434.16400 |
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| PSA | 52.01000 |
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| LogP | 4.47750 |
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| Index of Refraction | 1.607 |
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| InChIKey | NJMYODHXAKYRHW-UHFFFAOYSA-N |
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| SMILES | OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TL9900000
- CHEMICAL NAME :
- 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl )-
- CAS REGISTRY NUMBER :
- 2709-56-0
- LAST UPDATED :
- 199507
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C23-H25-F3-N2-O-S
- MOLECULAR WEIGHT :
- 434.56
- WISWESSER LINE NOTATION :
- T C666 BS IYJ IU3- AT6N DNTJ D2Q
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 900 ug/kg
- TOXIC EFFECTS :
- Behavioral - sleep Behavioral - changes in motor activity (specific assay) Behavioral - coma
- REFERENCE :
- DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 15,388,1981
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 367 ug/kg/12D-I
- TOXIC EFFECTS :
- Behavioral - wakefulness Behavioral - muscle weakness Behavioral - headache
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,93,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2121,1977
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Safety Information
| Hazard Codes | Xn: Harmful; |
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| Risk Phrases | R20/21/22 |
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| Safety Phrases | 36/37/39 |
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| RIDADR | UN 2811 6.1/PG 3 |
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| WGK Germany | 3 |
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| RTECS | TL9900000 |
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Synonyms
| n7009 |
| [3H]-(Z)-Flupentixol |
| siplaril |
| fluanxol |
| Flupentiol |
| fluxanxol |
| emergil |
| siplarol |
| lc44 |
| flupentixol |
