Introduction：Basic information about CAS 7298-99-9|L-Aspartic acid,3-hydroxy-, (3S)-, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | L-Aspartic acid,3-hydroxy-, (3S)- |
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| CAS Number | 7298-99-9 | Molecular Weight | 149.10 |
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| Density | 1.738 g/cm3 | Boiling Point | 368.7ºCat 760 mmHg |
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| Molecular Formula | C4H7NO5 | Melting Point | / |
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| MSDS | / | Flash Point | 176.8ºC |
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Names
| Name | (3S)-3-hydroxy-L-aspartic acid |
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| Synonym | More Synonyms |
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L-Aspartic acid,3-hydroxy-, (3S)- BiologicalActivity
| Description | L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersSignaling Pathways >>Membrane Transporter/Ion Channel >>EAAT2Research Areas >>Neurological Disease |
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| Target | Ki: 11 μM (EAAT1), 14 μM (EAAT3), 19 μM (EAAT2)[1] |
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| References | [1]. HaraR, et al Production of L-threo-3-Hydroxyaspartic Acid Using Asparaginase-DeficientEscherichia coli Expressing Asparagine Hydroxylase of Streptomyces coelicolorA3(2). Appl Environ Microbiol. 2015 Jun;81(11):3648-54 [2]. Jensen AA, Bräuner-Osborne H. Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2004 Jun 1;67(11):2115-27. |
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Chemical & Physical Properties
| Density | 1.738 g/cm3 |
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| Boiling Point | 368.7ºCat 760 mmHg |
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| Molecular Formula | C4H7NO5 |
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| Molecular Weight | 149.10 |
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| Flash Point | 176.8ºC |
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| Exact Mass | 149.03200 |
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| PSA | 120.85000 |
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| InChIKey | YYLQUHNPNCGKJQ-LWMBPPNESA-N |
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| SMILES | NC(C(=O)O)C(O)C(=O)O |
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| Storage condition | Store at RT |
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Synonyms
| (2S,3S)-2-amino-3-hydroxybutanedioic acid |
| W-7 hydrochloride |
