CAS 620112-78-9|CCG-63802

Introduction：Basic information about CAS 620112-78-9|CCG-63802, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. CCG-63802 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	CCG-63802
CAS Number	620112-78-9	Molecular Weight	450.51200
Density	1.31	Boiling Point	547.9ºC at 760 mmHg
Molecular Formula	C₂₆H₁₈N₄O₂S	Melting Point	/
MSDS	ChineseUSA	Flash Point	285.1ºC

Names

Name	(E)-2-(1,3-benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enenitrile
Synonym	More Synonyms

CCG-63802 BiologicalActivity

Description	CCG-63802 is a reversible inhibitor of regulator of G-protein signaling (RGS) protein; with greatest potency at RGS4.IC50 value:Target: RGSCCG-63802 is selective amongst RGS proteins, with greatest potency at RGS4. CCG-63802 inhibits GTPase accelerating protein activity of RGS4 and blocks its interaction with Gαo. Retains activity under reducing conditions.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>RGS ProteinResearch Areas >>Cancer
References	[1]. Blazer LL, et al. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Mol Pharmacol. 2010 Sep;78(3):524-33. [2]. Bosier B, et al. Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling. Br J Pharmacol. 2015 Nov;172(22):5333-46. [3]. Meng X, et al. PPARγ Agonist PGZ Attenuates OVA-Induced Airway Inflammation and Airway Remodeling via RGS4 Signaling in Mouse Model. Inflammation. 2018 Jul 19.

Description

CCG-63802 is a reversible inhibitor of regulator of G-protein signaling (RGS) protein; with greatest potency at RGS4.IC50 value:Target: RGSCCG-63802 is selective amongst RGS proteins, with greatest potency at RGS4. CCG-63802 inhibits GTPase accelerating protein activity of RGS4 and blocks its interaction with Gαo. Retains activity under reducing conditions.

Related Catalog

Signaling Pathways >>GPCR/G Protein >>RGS ProteinResearch Areas >>Cancer

References

[1]. Blazer LL, et al. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Mol Pharmacol. 2010 Sep;78(3):524-33.

[2]. Bosier B, et al. Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling. Br J Pharmacol. 2015 Nov;172(22):5333-46.

[3]. Meng X, et al. PPARγ Agonist PGZ Attenuates OVA-Induced Airway Inflammation and Airway Remodeling via RGS4 Signaling in Mouse Model. Inflammation. 2018 Jul 19.

Chemical & Physical Properties

Density	1.31
Boiling Point	547.9ºC at 760 mmHg
Molecular Formula	C₂₆H₁₈N₄O₂S
Molecular Weight	450.51200
Flash Point	285.1ºC
Exact Mass	450.11500
PSA	108.52000
LogP	5.77748
Index of Refraction	1.694
InChIKey	VFSVKVQMZDJFQX-NBVRZTHBSA-N
SMILES	Cc1cccc(Oc2nc3c(C)cccn3c(=O)c2C=C(C#N)c2nc3ccccc3s2)c1
Storage condition	2-8℃

Synonyms

unii-339bu4y35u

hms1804i11

CCG-63802

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