CAS 939983-14-9|p53 and MDM2 proteins-interaction-inhibitor (racemic)

Introduction：Basic information about CAS 939983-14-9|p53 and MDM2 proteins-interaction-inhibitor (racemic), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Namep53 and MDM2 proteins-interaction-inhibitor (racemic)
CAS Number939983-14-9Molecular Weight734.75400
Density1.24Boiling Point/
Molecular FormulaC40H49Cl2N5O4Melting Point/
MSDS/Flash Point/

Names

Name2-[4-[(4R,5S)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazole-1-carbonyl]piperazin-1-yl]-1-morpholin-4-ylethanone
SynonymMore Synonyms

BiologicalActivity

Descriptionp53 and MDM2 proteins-interaction-inhibitor (racemic) (Compound 2j) is an inhibitor of the interaction between p53 and MDM2 proteins.
Related CatalogSignaling Pathways >>Apoptosis >>MDM-2/p53Research Areas >>Cancer
References

[1]. Vu B, et al. Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development. ACS Med Chem Lett. 2013 Apr 2;4(5):466-9.

Chemical & Physical Properties

Density1.24
Molecular FormulaC40H49Cl2N5O4
Molecular Weight734.75400
Exact Mass733.31600
PSA77.92000
LogP6.36620
InChIKeyDJZBZZRLUQDRII-PVXQIPPMSA-N
SMILESCCOC1=C(C=CC(=C1)C(C)(C)C)C2=N[C@]([C@](N2C(=O)N3CCN(CC3)CC(=O)N4CCOCC4)(C)C5=CC=C(C=C5)Cl)(C)C6=CC=C(C=C6)Cl
Storage condition2-8℃

Synonyms

2-(4-((4R,5S)-2-(4-(tert-Butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)-1-morpholinoethanone
p53 and MDM2 proteins-interaction-inhibitor racemic
p53 and MDM2 proteins-interaction-inhibitor (racemic)
CAS 939981-35-8|(4R,5S)-2-(4-(TERT-BUTYL)-2-ETHOXYPHENYL)-4,5-BIS(4-CHLOROPHENYL)-4,5-DIMETHY
CAS 939983-16-1|4,4'-((2R,3S)-BUTANE-2,3-DIYL)BIS(CHLOROBENZENE)
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