Introduction：Basic information about CAS 2873-36-1|Cyclo(-leu-pro), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cyclo(-leu-pro) |
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| CAS Number | 2873-36-1 | Molecular Weight | 210.27 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 427.6±34.0 °C at 760 mmHg |
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| Molecular Formula | C11H18N2O2 | Melting Point | 163-165ºC |
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| MSDS | / | Flash Point | 212.4±25.7 °C |
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Names
| Name | 3-(2-methylpropyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione |
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| Synonym | More Synonyms |
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Cyclo(-leu-pro) BiologicalActivity
| Description | Cyclo(L-Leu-L-Pro) is an inhibitory substance targeting to production of norsolorinic acid (NA，a precursor of aflatoxin)，which can be isolated from A. xylosoxidans NFRI-A1. Cyclo(L-Leu-L-Pro) inhibits accumulation of NA by A. parasiticus NFRI-95 and inhibits spore formation. Cyclo(L-Leu-L-Pro) inhibits aflatoxin production with an IC50 of 0.2 mg/mL in A. parasiticus SYS-4[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Fungal |
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| References | [1]. Yan PS, et al. Cyclo(L-leucyl-L-prolyl) produced by Achromobacter xylosoxidans inhibits aflatoxin production by Aspergillus parasiticus. Appl Environ Microbiol. 2004 Dec;70(12):7466-73. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 427.6±34.0 °C at 760 mmHg |
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| Melting Point | 163-165ºC |
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| Molecular Formula | C11H18N2O2 |
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| Molecular Weight | 210.27 |
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| Flash Point | 212.4±25.7 °C |
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| Exact Mass | 210.136826 |
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| PSA | 49.41000 |
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| LogP | -0.84 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.530 |
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| InChIKey | SZJNCZMRZAUNQT-IUCAKERBSA-N |
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| SMILES | CC(C)CC1NC(=O)C2CCCN2C1=O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UY8708800
- CHEMICAL NAME :
- Pyrrolo(1,2-a)pyrazine-1,4-dione, hexahydro-3-isobutyl-, stereoisomer
- CAS REGISTRY NUMBER :
- 2873-36-1
- BEILSTEIN REFERENCE NO. :
- 0085716
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C11-H18-N2-O2
- MOLECULAR WEIGHT :
- 210.31
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - facilitates action of known carcinogen
- REFERENCE :
- 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 2,1354,1978
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Gancidin W |
| CYCLO(L-LEU-L-PRO) |
| (3S-trans)-Hexahydro-3-isobutylpyrrolo(1,2-a)pyrazine-1,4-dione |
| Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl)-, (3S,8aS)- |
| cyclo-L-Leu-L-Pro |
| EINECS 220-710-6 |
| (3S,8aS)-3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione |
| Cyclo(-Leu-Pro) |
