CAS 1164470-53-4|Sal003

Introduction：Basic information about CAS 1164470-53-4|Sal003, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Sal003 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles6
6. Synonyms

Common Name	Sal003
CAS Number	1164470-53-4	Molecular Weight	463.208
Density	1.5±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₁₈H₁₅Cl₄N₃OS	Melting Point	/
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS09	Signal Word	Warning

Names

Name	(2E)-3-Phenyl-N-(2,2,2-trichloro-1-{[(4-chlorophenyl)carbamothioy l]amino}ethyl)acrylamide
Synonym	More Synonyms

Sal003 BiologicalActivity

Description	Sal003 is a potent cell-permeable analog of the eIF2α phosphatase inhibitor Salubrinal with enhanced aqueous solubility.IC50 value:Target: eIF2α phosphatase inhibitorSal003 has been shown to prevent dephosphorylation of eIF-2α which has been shown to regulate the late phase of long-term potentiation (LTP) and memory (LTM). This enhanced phosphorylated state of eIF-2α is shown to prevent L-LTP and suppress memory in mice.
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>PhosphataseResearch Areas >>Cancer
References	[1]. Xia F, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45. [2]. Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305. [3]. Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51.

Description

Sal003 is a potent cell-permeable analog of the eIF2α phosphatase inhibitor Salubrinal with enhanced aqueous solubility.IC50 value:Target: eIF2α phosphatase inhibitorSal003 has been shown to prevent dephosphorylation of eIF-2α which has been shown to regulate the late phase of long-term potentiation (LTP) and memory (LTM). This enhanced phosphorylated state of eIF-2α is shown to prevent L-LTP and suppress memory in mice.

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>PhosphataseResearch Areas >>Cancer

References

[1]. Xia F, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45.

[2]. Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305.

[3]. Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Molecular Formula	C₁₈H₁₅Cl₄N₃OS
Molecular Weight	463.208
Exact Mass	460.968994
PSA	95.78000
LogP	6.20
Index of Refraction	1.694
InChIKey	TVNBASWNLOIQML-IZZDOVSWSA-N
SMILES	O=C(C=Cc1ccccc1)NC(NC(=S)Nc1ccc(Cl)cc1)C(Cl)(Cl)Cl
Storage condition	-20℃

Safety Information

Symbol	GHS09
Signal Word	Warning
Hazard Statements	H410
Precautionary Statements	P273-P501
Hazard Codes	N
RIDADR	UN 3077 9 / PGIII

Articles6

Translational Control of Long-Lasting Synaptic Plasticity and Memory

Neuron 61(1) , 10-26, (2009)

Long-lasting forms of synaptic plasticity and memory are dependent on new protein synthesis. Recent advances obtained from genetic, physiological, pharmacological, and biochemical studies provide stro...

Regulation of subtilase cytotoxin-induced cell death by an RNA-dependent protein kinase-like endoplasmic reticulum kinase-dependent proteasome pathway in HeLa cells.

Infect. Immun. 80(5) , 1803-14, (2012)

Shiga-toxigenic Escherichia coli (STEC) produces subtilase cytotoxin (SubAB), which cleaves the molecular chaperone BiP in the endoplasmic reticulum (ER), leading to an ER stress response and then act...

Switching gears: translational mastery of transcription during memory formation.

Neuron 54(2) , 186-9, (2007)

A critical molecular requirement underlying many forms of long-lasting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins. In a recent paper in Cell, Costa-Mattioli et al. p...

Synonyms

(2E)-3-Phenyl-N-(2,2,2-trichloro-1-{[(4-chlorophenyl)carbamothioyl]amino}ethyl)acrylamide

(E)-1-(4-chlorophenyl)-3-(1,1,1-trichloro-4-oxo-6-phenylhex-5-en-2-yl)thiourea

2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-, (2E)-

Sal003

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