CAS 147591-46-6|ID 8

Introduction：Basic information about CAS 147591-46-6|ID 8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. ID 8 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles1
6. Synonyms

Common Name	ID 8
CAS Number	147591-46-6	Molecular Weight	298.293
Density	1.3±0.1 g/cm3	Boiling Point	418.3±45.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₄N₂O₄	Melting Point	266 °C(dec.)
MSDS	ChineseUSA	Flash Point	206.8±28.7 °C
Symbol	GHS07, GHS09	Signal Word	Warning

Names

Name	1-(4-methoxyphenyl)-2-methyl-3-nitroindol-6-ol
Synonym	More Synonyms

ID 8 BiologicalActivity

Description	ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.IC50 Value: Target: DYRKin vitro: the combination of Wnt and ID-8 enhanced hESC replating efficiency, and colonies expressed ALP and displayed undifferentiated morphology. members of the DYRK family are direct targets of ID-8 and that ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs [1]. ID-8 stimulated proliferation at a steady rate similar to LIF. ID-8 is required to maintain nanog, Sox2, and Rex-1 gene expression [2]. In vivo:
Related Catalog	Signaling Pathways >>Protein Tyrosine Kinase/RTK >>DYRKResearch Areas >>Cancer
References	[1]. Hasegawa, K., et al., Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl Med, 2012. 1(1): p. 18-28. [2]. Miyabayashi, T., et al., Indole derivatives sustain embryonic stem cell self-renewal in long-term culture. Biosci Biotechnol Biochem, 2008. 72(5): p. 1242-8.

Description

ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.IC50 Value: Target: DYRKin vitro: the combination of Wnt and ID-8 enhanced hESC replating efficiency, and colonies expressed ALP and displayed undifferentiated morphology. members of the DYRK family are direct targets of ID-8 and that ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs [1]. ID-8 stimulated proliferation at a steady rate similar to LIF. ID-8 is required to maintain nanog, Sox2, and Rex-1 gene expression [2]. In vivo:

Related Catalog

Signaling Pathways >>Protein Tyrosine Kinase/RTK >>DYRKResearch Areas >>Cancer

References

[1]. Hasegawa, K., et al., Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl Med, 2012. 1(1): p. 18-28.

[2]. Miyabayashi, T., et al., Indole derivatives sustain embryonic stem cell self-renewal in long-term culture. Biosci Biotechnol Biochem, 2008. 72(5): p. 1242-8.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	418.3±45.0 °C at 760 mmHg
Melting Point	266 °C(dec.)
Molecular Formula	C₁₆H₁₄N₂O₄
Molecular Weight	298.293
Flash Point	206.8±28.7 °C
Exact Mass	298.095367
PSA	80.21000
LogP	4.13
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.638
InChIKey	VVZNWYXIOADGSW-UHFFFAOYSA-N
SMILES	COc1ccc(-n2c(C)c([N+](=O)[O-])c3ccc(O)cc32)cc1

Safety Information

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H400
Precautionary Statements	P273
RIDADR	UN 3077 9 / PGIII

Articles1

Validation of Perfusion Quantification with 3D Gradient Echo Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using a Blood Pool Contrast Agent in Skeletal Swine Muscle.

PLoS ONE 10 , e0128060, (2015)

The purpose of our study was to validate perfusion quantification in a low-perfused tissue by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with shared k-space sampling using a blood ...

Synonyms

1-(4-Methoxy-phenyl)-2-methyl-3-nitro-1H-indol-6-ol

1H-Indol-6-ol, 1-(4-methoxyphenyl)-2-methyl-3-nitro-

ID-8

1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol

1-(4-methoxy-phenyl)-2-methyl-3-nitro-1H-indole-6-ol

ID8

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