CAS 486427-17-2|CIQ

Introduction：Basic information about CAS 486427-17-2|CIQ, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. CIQ BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	CIQ
CAS Number	486427-17-2	Molecular Weight	467.941
Density	1.2±0.1 g/cm3	Boiling Point	635.8±55.0 °C at 760 mmHg
Molecular Formula	C₂₆H₂₆ClNO₅	Melting Point	/
MSDS	USA	Flash Point	338.3±31.5 °C
Symbol	GHS09	Signal Word	Warning

Names

Name	(3-Chlorophenyl){6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-3,4-d ihydro-2(1H)-isoquinolinyl}methanone
Synonym	More Synonyms

CIQ BiologicalActivity

Description	CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. IC50 value: 2.7 μM (EC50, for NR2C) and 2.8 μM (EC50, NR2D)Target: NMDA receptorCIQ increases channel opening frequency of recombinant NR2Cor NR2D containing receptors by two-fold (EC50 = 2.7 and 2.8 μM, respectively), with no effect on NR2A or NR2B subtypes. CIQ does not alter the EC50 values for glutamate or glycine on channel opening. CIQ increases channel opening efficiency and enhances NMDA receptor responses. CIQ reduces associated behaviours in schizophrenia models and potentially enhances dopamine release in Parkinson's disease models.
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>iGluRSignaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological Disease

Description

CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. IC50 value: 2.7 μM (EC50, for NR2C) and 2.8 μM (EC50, NR2D)Target: NMDA receptorCIQ increases channel opening frequency of recombinant NR2Cor NR2D containing receptors by two-fold (EC50 = 2.7 and 2.8 μM, respectively), with no effect on NR2A or NR2B subtypes. CIQ does not alter the EC50 values for glutamate or glycine on channel opening. CIQ increases channel opening efficiency and enhances NMDA receptor responses. CIQ reduces associated behaviours in schizophrenia models and potentially enhances dopamine release in Parkinson's disease models.

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>iGluRSignaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological Disease

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	635.8±55.0 °C at 760 mmHg
Molecular Formula	C₂₆H₂₆ClNO₅
Molecular Weight	467.941
Flash Point	338.3±31.5 °C
Exact Mass	467.149963
PSA	57.23000
LogP	4.56
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.590
InChIKey	VYMILMYEENZHAR-UHFFFAOYSA-N
SMILES	COc1ccc(OCC2c3cc(OC)c(OC)cc3CCN2C(=O)c2cccc(Cl)c2)cc1
Storage condition	2-8℃

Safety Information

Symbol	GHS09
Signal Word	Warning
Hazard Statements	H410
Precautionary Statements	P273-P501
RIDADR	UN 3077 9 / PGIII

Synonyms

Methanone, (3-chlorophenyl)[3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]-

(3-Chlorophenyl){6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-3,4-dihydro-2(1H)-isoquinolinyl}methanone

Altanserin hydrochloride

CIQ

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