Introduction：Basic information about CAS 944154-76-1|MJ 15, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | MJ 15 |
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| CAS Number | 944154-76-1 | Molecular Weight | 471.76600 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C23H17Cl3N4O | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(3-pyridinyl methyl)-1H-pyrazole-3-carboxamide |
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| Synonym | More Synonyms |
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MJ 15 BiologicalActivity
| Description | MJ15 is a potent and selective CB1 receptor antagonist with a Ki of 27.2 pM and an IC50 of 118.9 pM for rat CB1 receptors. MJ15 exhibits potency in obesity and hyperlipidemia models. MJ15 inhibits food intake and increases in body weight in diet-induced obese rats and mice[1]. |
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| Related Catalog | Research Areas >>Metabolic DiseaseSignaling Pathways >>GPCR/G Protein >>Cannabinoid Receptor |
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| Target | rCB1-R:27.2 pM (Ki) rCB1-R:118.9 pM (IC50) |
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| References | [1]. Chen W, et al. Novel selective antagonist of the cannabinoid CB1 receptor, MJ15, with prominent anti-obesity effect in rodent models. Eur J Pharmacol. 2010 Jul 10;637(1-3):178-85. |
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Chemical & Physical Properties
| Molecular Formula | C23H17Cl3N4O |
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| Molecular Weight | 471.76600 |
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| Exact Mass | 470.04700 |
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| PSA | 63.30000 |
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| LogP | 6.70770 |
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| InChIKey | PJEIKJFNEFJFLA-UHFFFAOYSA-N |
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| SMILES | Cc1c(C(=O)NCc2cccnc2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1 |
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Synonyms
| N-(3-aminomethyl-pyridin-2-yl)-N-methyl-methanesulphonamide |
| N-(3-(aminomethyl)pyridin-2-yl)-N-methylmethanesulfonamide |
| N-(3-aminomethylpyridyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl pyrazol-3-carboxamide |
