Introduction：Basic information about CAS 932986-18-0|Azoramide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Azoramide |
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| CAS Number | 932986-18-0 | Molecular Weight | 308.826 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C15H17ClN2OS | Melting Point | / |
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| MSDS | USA | Flash Point | / |
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Names
| Name | N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide |
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| Synonym | More Synonyms |
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Azoramide BiologicalActivity
| Description | Azoramide is a small-molecule modulator of the unfolded protein response with antidiabetic activity.in vitro: Azoramide is a dual-function endoplasmic reticulum (ER) modulator. Azoramide improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress in multiple systems. Azoramide regulates ER folding and secretion capacity without inducing ER stress. Azoramide might have the protective effects of enhancing chaperone expression and reducing protein synthesis without inducing cytotoxicity and apoptosis.in vivo: Azoramide exhibits potent antidiabetic efficacy in two independent mouse models of obesity by improving insulin sensitivity and pancreatic β cell function. Azoramide improves glucose homeostasis in mice with genetic obesity. Azoramide improves glucose homeostasis in mice with diet-induced obesity. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Endocrinology |
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| References | [1]. Fu S, et al. Sci Transl Med. 2015 Jun 17;7(292):292ra98. doi: 10.1126/scitranslmed.aaa9134. Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response withantidiabetic activity. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Molecular Formula | C15H17ClN2OS |
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| Molecular Weight | 308.826 |
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| Exact Mass | 308.075012 |
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| PSA | 73.72000 |
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| LogP | 3.97 |
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| Index of Refraction | 1.574 |
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| InChIKey | VYBFWKKCWTXCQX-UHFFFAOYSA-N |
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| SMILES | CCCC(=O)NCCc1csc(-c2ccc(Cl)cc2)n1 |
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| Storage condition | 2-8°C |
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Safety Information
| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| N-(2-(2-(4-Chlorophenyl)thiazol-4-yl)ethyl)butyramide |
| SC1362 |
| Butanamide, N-[2-[2-(4-chlorophenyl)-4-thiazolyl]ethyl]- |
| N-{2-[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]ethyl}butanamide |
| Azoramide |
