CAS 942999-61-3|DGAT-1 inhibitor 2

Introduction：Basic information about CAS 942999-61-3|DGAT-1 inhibitor 2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. DGAT-1 inhibitor 2 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	DGAT-1 inhibitor 2
CAS Number	942999-61-3	Molecular Weight	420.50400
Density	/	Boiling Point	/
Molecular Formula	C₂₄H₂₈N₄O₃	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	2-[4-[4-(4-amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-1-bicyclo[2.2.2]octanyl]acetic acid
Synonym	More Synonyms

DGAT-1 inhibitor 2 BiologicalActivity

Description	DGAT-1 inhibitor 2 is an effective inhibitor of DGAT-1;antiobesity agents.IC50 value:Target: DGAT-1Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step in triglyceride synthesis. Findings from genetically modified mice as well as pharmacological studies suggest that inhibition of DGAT1 is a promising strategy for the treatment of obesity and type 2 diabetes.
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>AcyltransferaseResearch Areas >>Metabolic Disease
References	[1]. Matsuda D, Tomoda H. DGAT inhibitors for obesity. Curr Opin Investig Drugs. 2007 Oct;8(10):836-41. [2]. Birch, Alan M.; Birtles, Susan; Buckett, Linda K. et al. Discovery of a Potent, Selective, and Orally Efficacious Pyrimidinooxazinyl Bicyclooctaneacetic Acid Diacylglycerol Acyltransferase-1 Inhibitor. Journal of Medicinal Chemistry (2009), 52(6), 1558-15 [3]. King AJ, Judd AS, Souers AJ. Inhibitors of diacylglycerol acyltransferase: a review of 2008 patents. Expert Opin Ther Pat. 2010 Jan;20(1):19-29. [4]. Cao J, Zhou Y, Peng H et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem. 2011 Dec 2;286(48):41838-51.

Description

DGAT-1 inhibitor 2 is an effective inhibitor of DGAT-1;antiobesity agents.IC50 value:Target: DGAT-1Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step in triglyceride synthesis. Findings from genetically modified mice as well as pharmacological studies suggest that inhibition of DGAT1 is a promising strategy for the treatment of obesity and type 2 diabetes.

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>AcyltransferaseResearch Areas >>Metabolic Disease

References

[1]. Matsuda D, Tomoda H. DGAT inhibitors for obesity. Curr Opin Investig Drugs. 2007 Oct;8(10):836-41.

[2]. Birch, Alan M.; Birtles, Susan; Buckett, Linda K. et al. Discovery of a Potent, Selective, and Orally Efficacious Pyrimidinooxazinyl Bicyclooctaneacetic Acid Diacylglycerol Acyltransferase-1 Inhibitor. Journal of Medicinal Chemistry (2009), 52(6), 1558-15

[3]. King AJ, Judd AS, Souers AJ. Inhibitors of diacylglycerol acyltransferase: a review of 2008 patents. Expert Opin Ther Pat. 2010 Jan;20(1):19-29.

[4]. Cao J, Zhou Y, Peng H et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem. 2011 Dec 2;286(48):41838-51.

Chemical & Physical Properties

Molecular Formula	C₂₄H₂₈N₄O₃
Molecular Weight	420.50400
Exact Mass	420.21600
PSA	110.69000
LogP	4.43410
InChIKey	VGPKUACRBMPJLF-UHFFFAOYSA-N
SMILES	CC1(C)Oc2ncnc(N)c2N=C1c1ccc(C23CCC(CC(=O)O)(CC2)CC3)cc1
Storage condition	2-8℃

Synonyms

DGAT-1 inhibitor 2||Bicyclo[2.2.2]octane-1-acetic acid,4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]

DGAT-1 inhibitor 2

bicyclo[2.2.2]octane-pyrimido[4,5-b][1,4]oxazine deriv.,4

Bicyclo[2.2.2]octane-1-acetic acid,4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]

CS-0982

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