Introduction：Basic information about CAS 6640-22-8|Pamoic acid disodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pamoic acid disodium |
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| CAS Number | 6640-22-8 | Molecular Weight | 432.333 |
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| Density | / | Boiling Point | 642.7ºC at 760 mmHg |
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| Molecular Formula | C23H14Na2O6 | Melting Point | 300 °C |
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| MSDS | / | Flash Point | 356.5ºC |
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Names
| Name | disodium,3-carboxy-1-[(3-carboxy-2-oxidonaphthalen-1-yl)methyl]naphthalen-2-olate |
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| Synonym | More Synonyms |
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Pamoic acid disodium BiologicalActivity
| Description | Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect[1]. |
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| Related Catalog | Signaling Pathways >>MAPK/ERK Pathway >>ERKResearch Areas >>Neurological DiseaseSignaling Pathways >>Stem Cell/Wnt >>ERK |
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| Target | EC50: 79 nM (GPR35), 65 nM (ERK1/2)[1] |
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| References | [1]. Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78(4):560-8. |
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Chemical & Physical Properties
| Boiling Point | 642.7ºC at 760 mmHg |
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| Melting Point | 300 °C |
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| Molecular Formula | C23H14Na2O6 |
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| Molecular Weight | 432.333 |
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| Flash Point | 356.5ºC |
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| Exact Mass | 432.058563 |
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| PSA | 120.72000 |
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| LogP | 1.72200 |
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| InChIKey | YGLLICRFEVEWOZ-UHFFFAOYSA-L |
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| SMILES | O=C(O)c1cc2ccccc2c(Cc2c([O-])c(C(=O)O)cc3ccccc23)c1[O-].[Na+].[Na+] |
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | R20/21/22 |
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| Safety Phrases | S24/25 |
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Synonyms
| Pamoic acid disodium salt |
| embonic acid disodium salt |
| MFCD00036183 |
| pamoate disodique |
| disodium 4,4'-methylene-bis(3-hydroxy-2-naphthoate) |
| dipotassium pamoate(2-) |
| sodium embonate |
| Disodium 4,4'-methylenebis(3-hydroxy-2-naphthoate) |
| Pamoic acid,disodium salt |
| PAMOIC ACID,Na |
| Sodium pamoate |
| disodium 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylate |
| Disodium pamoate |
| disodium 4-[(3-carboxylato-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylate |
| 2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, sodium salt (1:2) |
| Disodium methylenebis(2-hydroxy-3-naphthoate) |
| EINECS 229-653-1 |
