Introduction：Basic information about CAS 66756-57-8|diosbulbin d, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | diosbulbin d |
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| CAS Number | 66756-57-8 | Molecular Weight | 344.36 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 599.1±50.0 °C at 760 mmHg |
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| Molecular Formula | C19H20O6 | Melting Point | / |
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| MSDS | / | Flash Point | 316.2±30.1 °C |
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Names
| Name | 2-(furan-3-yl)-11b-methyloctahydro-2h-7,10-methanooxepino[4,5-f]isochromene-4,6,8(1h)-trione |
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| Synonym | More Synonyms |
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diosbulbin d BiologicalActivity
| Description | Diosbulbin D is a potential hepatotoxic compound that can be isolated from Dioscorea bulbifera L.. Diosbulbin D induces apoptosis in L-02 cells[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Metabolic Disease |
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| In Vitro | Diosbulbin D (10-80 μM; 12-72 h) 可诱导人正常肝脏 L-02 细胞毒性[1]。 Diosbulbin D (40 μM; 24 h) 诱导 L-02 细胞形态改变[1]。 Diosbulbin D (20-80 μM; 12-48 h) 诱导 L-02 细胞凋亡，并呈时间和浓度依赖性[1]。 Diosbulbin D (20-80 μM; 24 h) 诱导 L-02 细胞 caspase 3 的激活[1]。 Cell Viability Assay[1] Cell Line: L-02 cells Concentration: 10, 20, 40 and 80 μM Incubation Time: 12, 24, 48 and 72 h Result: Decreased L-02 cells viability in a concentration- and time-dependent manner. Apoptosis Analysis[1] Cell Line: L-02 cells Concentration: 20, 40 and 80 μM Incubation Time: 12, 24 and 48 h Result: Induced apoptosis in a time- and concentration-dependent manner. |
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| References | [1]. Ma M, et al. The furano norclerodane diterpenoid disobulbin-D induces apoptosis in normal human liver L-02 cells. Exp Toxicol Pathol. 2012 Sep;64(6):611-8. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 599.1±50.0 °C at 760 mmHg |
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| Molecular Formula | C19H20O6 |
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| Molecular Weight | 344.36 |
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| Flash Point | 316.2±30.1 °C |
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| Exact Mass | 344.125977 |
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| PSA | 82.81000 |
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| LogP | -0.35 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.556 |
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| InChIKey | FJCWYLRNGKSUCH-UHFFFAOYSA-N |
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| SMILES | CC12CC(c3ccoc3)OC(=O)C1CC(=O)C1C3CC(CC12)OC3=O |
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Safety Information
Synonyms
| (1S,2S,5S,8S,10R,11R,13S)-8-(3-Furyl)-10-methyl-7,14-dioxatetracyclo[11.2.1.0.0]hexadecane-3,6,15-trione |
| 7,10-Methano-2H-pyrano[4,3-g][3]benzoxepin-4,6,8(1H)-trione, 2-(3-furanyl)octahydro-11b-methyl-, (2S,4aS,6aS,7S,10S,11aR,11bR)- |
| 7,10-Methano-2H-pyrano[4,3-g][3]benzoxepin-4,6,8(1H)-trione, 2-(3-furanyl)octahydro-11b-methyl- |
| 8-(3-Furyl)-10-methyl-7,14-dioxatetracyclo[11.2.1.0.0]hexadecane-3,6,15-trione |
| diosbulbin-d |
