CAS 4697-36-3|Carbenicillin

Introduction：Basic information about CAS 4697-36-3|Carbenicillin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Carbenicillin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Synonyms

Common Name	Carbenicillin
CAS Number	4697-36-3	Molecular Weight	378.40000
Density	1.53g/cm3	Boiling Point	737.8ºC at 760mmHg
Molecular Formula	C₁₇H₁₈N₂O₆S	Melting Point	/
MSDS	ChineseUSA	Flash Point	400ºC

Names

Name	carbenicillin
Synonym	More Synonyms

Carbenicillin BiologicalActivity

Description	Carbenicillin is broad-spectrum semisynthetic penicillin derivative used parenterally.Target: AntibacterialCarbenicillin is a semi-synthetic penicillin antibiotic which interferes with cell wall synthesis of gram-negative bacteria while displaying low toxicity. The leukocytes of the patients does not release histamine on in vitro provocation with Carbenicillin (0.1 g/mL). Carbenicillin (0.1 g/mL) does not show any allergic drug reactions in cystic fibrosis patients, as evident by no significant levels of antibodies of IgE, IgG or IgM classes [1]. Carbenicillin (50 μg/mL) results in phytotoxicity in chrysanthemum and TOB, with an increase in the concentration, and with a parallel shift in the morphogenic capacity (SRC) of threshold survival levels (TSLs). Carbenicillin results in 100% acclimatization with no different morphological flowering characteristics following subculture in vitro three times in Chrysanthemum plantlets [2].
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection
References	[1]. Moller, N.E., et al., Allergological examination of cystic fibrosis patients with skin reactions during carbenicillin treatment. Allergy, 1980. 35(2): p. 135-8. [2]. Silva, J.d. and S. Fukai, The impact of carbenicillin, cefotaxime and vancomycin on chrysanthemum and tobacco TCL morphogenesis and Agrobacterium growth. J. Appl. Hort, 2001. 3(1): p. 3-12.

Description

Carbenicillin is broad-spectrum semisynthetic penicillin derivative used parenterally.Target: AntibacterialCarbenicillin is a semi-synthetic penicillin antibiotic which interferes with cell wall synthesis of gram-negative bacteria while displaying low toxicity. The leukocytes of the patients does not release histamine on in vitro provocation with Carbenicillin (0.1 g/mL). Carbenicillin (0.1 g/mL) does not show any allergic drug reactions in cystic fibrosis patients, as evident by no significant levels of antibodies of IgE, IgG or IgM classes [1]. Carbenicillin (50 μg/mL) results in phytotoxicity in chrysanthemum and TOB, with an increase in the concentration, and with a parallel shift in the morphogenic capacity (SRC) of threshold survival levels (TSLs). Carbenicillin results in 100% acclimatization with no different morphological flowering characteristics following subculture in vitro three times in Chrysanthemum plantlets [2].

Related Catalog

Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection

References

[1]. Moller, N.E., et al., Allergological examination of cystic fibrosis patients with skin reactions during carbenicillin treatment. Allergy, 1980. 35(2): p. 135-8.

[2]. Silva, J.d. and S. Fukai, The impact of carbenicillin, cefotaxime and vancomycin on chrysanthemum and tobacco TCL morphogenesis and Agrobacterium growth. J. Appl. Hort, 2001. 3(1): p. 3-12.

Chemical & Physical Properties

Density	1.53g/cm3
Boiling Point	737.8ºC at 760mmHg
Molecular Formula	C₁₇H₁₈N₂O₆S
Molecular Weight	378.40000
Flash Point	400ºC
Exact Mass	378.08900
PSA	149.31000
LogP	0.81530
Index of Refraction	1.675
InChIKey	FPPNZSSZRUTDAP-UWFZAAFLSA-N
SMILES	CC1(C)SC2C(NC(=O)C(C(=O)O)c3ccccc3)C(=O)N2C1C(=O)O
Storage condition	−20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ON9104700

CHEMICAL NAME :: Malonamic acid, N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3 .2.0)hept-6-yl)-2- phenyl-

CAS REGISTRY NUMBER :: 4697-36-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C17-H18-N2-O6-S

MOLECULAR WEIGHT :: 378.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2363 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 280 mg/L

REFERENCE :: HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 3,173,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3591 No. of Facilities: 178 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 10079 (estimated) No. of Female Employees: 8399 (estimated)

Safety Information

Hazard Codes	Xn
Risk Phrases	R10
Safety Phrases	36/37
RIDADR	UN 1170 3/PG 3
WGK Germany	2

Synonyms

Carboxybenzylpenicillin

(2S,5R,6R)-6-[(2-carboxy-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

CBPC

Carbenicilline

Geopen

Carbenicilina

Pyopen

Carboxybenzylpenicillin acid

Carbenicillinum

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