Introduction：Basic information about CAS 74713-60-3|C12-Ceramide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | C12-Ceramide |
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| CAS Number | 74713-60-3 | Molecular Weight | 481.79 |
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| Density | 0.9±0.1 g/cm3 | Boiling Point | 636.1±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H59NO3 | Melting Point | / |
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| MSDS | / | Flash Point | 338.5±31.5 °C |
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Names
| Name | N-dodecanoylsphingosine |
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| Synonym | More Synonyms |
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C12-Ceramide BiologicalActivity
| Description | C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease[1][1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
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| In Vitro | C12-Ceramide (1 μM; 24-72 h) enhances the liposomal Doxorubicin toxicity in MDA-MB-231 cells[1]. |
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| References | [1]. He X, et, al. A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease. Anal Biochem. 2003 Mar 1;314(1):116-20. [2]. Øverbye A, et, al. Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide. Oncotarget. 2017 Aug 12;8(44):76921-76934. |
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Chemical & Physical Properties
| Density | 0.9±0.1 g/cm3 |
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| Boiling Point | 636.1±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H59NO3 |
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| Molecular Weight | 481.79 |
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| Flash Point | 338.5±31.5 °C |
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| Exact Mass | 481.449493 |
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| PSA | 69.56000 |
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| LogP | 11.21 |
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| Vapour Pressure | 0.0±4.3 mmHg at 25°C |
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| Index of Refraction | 1.481 |
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| InChIKey | HXFPPRPLRSPNIB-VARSQMIESA-N |
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| SMILES | CCCCCCCCCCCCCC=CC(O)C(CO)NC(=O)CCCCCCCCCCC |
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| Storage condition | -20°C |
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Safety Information
| Safety Phrases | S24/25 |
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| HS Code | 2924199090 |
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Customs
| HS Code | 2924199090 |
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| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| N-[(2S,3R,4E)-1,3-Dihydroxy-4-octadecen-2-yl]dodecanamide |
| N-((1S,2R)-2-hydroxy-1-hydroxymethyl-heptadec-3t-enyl)-lauramide |
| Dodecanamide, N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]- |
| Laurylsphingosine |
| D-erthro-2-Lauroylamino-octadec-4t-en-1,3-diol |
| C12 Ceramide |
| N-((1S,2R)-2-Hydroxy-1-hydroxymethyl-heptadec-3t-enyl)-lauramid |
| N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]dodecanamide |
| N-(dodecanoyl)ceramide |
| Dodecyl sphingosine |
| N-Laurylsphingosine |
| N-Lauroylsphingosine |
| Cer(d18:1/12:0) |
| N-lauroyl-D-erythro-Sphingosine |
| N-[(E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]dodecanamide |
| N-(lauroyl)ceramide |
