Introduction：Basic information about CAS 32476-67-8|Periplocymarin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Periplocymarin |
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| CAS Number | 32476-67-8 | Molecular Weight | 534.68100 |
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| Density | 1.27±0.1 g/cm3 (20 ºC 760 Torr) | Boiling Point | 690.9±55.0℃ at 760 mmHg |
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| Molecular Formula | C30H46O8 | Melting Point | 209-211 ºC |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-[(3S,5S,10R,13R,14S,17S)-5,14-dihydroxy-3-[(2S,5R)-5-hydroxy-4-methoxy-6-methyl-oxan-2-yl]oxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one |
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| Synonym | More Synonyms |
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Periplocymarin BiologicalActivity
| Description | Periplocymarin, a cardiac glycoside isolated from Periploca sepium and Periploca graeca, is a potential anti-cancer compound[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| In Vitro | Periplocymarin inhibits proliferation of PC3, U937, HCT-8, Bel-7402, BGC823, A549, and A2780 cell lines in vitro with IC50 values of 0.02-0.29 µM[2]. |
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| References | [1]. Martey ON, et al. Periplocymarin is a potential natural compound for drug development: highly permeable with absence of P-glycoprotein efflux and cytochrome P450 inhibitions. Biopharm Drug Dispos. 2014 May;35(4):195-206. [2]. Redox-responsive PEGylated self-assembled prodrug-nanoparticles formed by single disulfidebond bridge periplocymarin-vitamin E conjugate for liver cancer chemotherapy. Drug Deliv. 2017 Nov;24(1):1170-1178. |
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Chemical & Physical Properties
| Density | 1.27±0.1 g/cm3 (20 ºC 760 Torr) |
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| Boiling Point | 690.9±55.0℃ at 760 mmHg |
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| Melting Point | 209-211 ºC |
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| Molecular Formula | C30H46O8 |
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| Molecular Weight | 534.68100 |
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| Exact Mass | 534.31900 |
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| PSA | 114.68000 |
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| LogP | 3.25430 |
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| InChIKey | XRWQBDJPMXRDOQ-YUUDFPFBSA-N |
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| SMILES | COC1CC(OC2CCC3(C)C4CCC5(C)C(C6=CC(=O)OC6)CCC5(O)C4CCC3(O)C2)OC(C)C1O |
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| Water Solubility | Very slightly soluble (0.43 g/L) (25 ºC) |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- FH4920610
- CHEMICAL NAME :
- 5-beta-Card-20(22)-enolide, 3-beta-((2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyran osyl)oxy)- 5,14-dihydroxy-
- CAS REGISTRY NUMBER :
- 32476-67-8
- LAST UPDATED :
- 199304
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C30-H46-O8
- MOLECULAR WEIGHT :
- 534.76
- WISWESSER LINE NOTATION :
- L E5 B666TJ A1 E1 IQ MQ F- DT5OV EHJ& OO- FT6OTJ B1 CQ DO1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 155 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 74,223,1942
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Synonyms
