CAS 220953-69-5|Antalarmin hydrochloride
| Common Name | Antalarmin hydrochloride | ||
|---|---|---|---|
| CAS Number | 220953-69-5 | Molecular Weight | 415.014 |
| Density | / | Boiling Point | / |
| Molecular Formula | C24H35ClN4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | Antalarmin hydrochloride |
|---|---|
| Synonym | More Synonyms |
Antalarmin hydrochloride BiologicalActivity
| Description | Antalarmin (hydrochloride) is a non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist with a Ki of 1 nM. Antalarmin hydrochloride suppresses CRH-induced ACTH secretion and blocks CRH and novelty induced anxiety-like behavior in animal models. Antalarmin hydrochloride produces anti-inflammatory effects in arthritis models, and suppresses stress-induced gastric ulceration related to irritable bowel syndrome[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>EndocrinologySignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
| References | [1]. Webster EL, et al. In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation. Endocrinology. 1996 Dec;137(12):5747-50. doi: 10.1210/endo.137.12.8940412. [2]. Zorrilla EP, et al. Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Res. 2002 Oct 18;952(2):188-99. [3]. Deak T, et al. The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress. Endocrinology. 1999 Jan;140(1):79-86. |
Chemical & Physical Properties
| Molecular Formula | C24H35ClN4 |
|---|---|
| Molecular Weight | 415.014 |
| Exact Mass | 414.255035 |
| PSA | 33.95000 |
| LogP | 6.69930 |
| InChIKey | CGDGXEDXEXACKQ-UHFFFAOYSA-N |
| SMILES | CCCCN(CC)c1nc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C.Cl |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles9
More Articles| Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat. Commun. 6 , 6770, (2015) Increased anxiety is a prominent withdrawal symptom in abstinent smokers, yet the neuroanatomical and molecular bases underlying it are unclear. Here we show that withdrawal-induced anxiety increases ... | |
| CRF-amplified neuronal TLR4/MCP-1 signaling regulates alcohol self-administration. Neuropsychopharmacology 40(6) , 1549-59, (2015) Alcohol dependence is a complex disorder that initiates with episodes of excessive alcohol drinking known as binge drinking. It has a 50-60% risk contribution from inherited susceptibility genes; howe... | |
| Stress during a critical postnatal period induces region-specific structural abnormalities and dysfunction of the prefrontal cortex via CRF1. Neuropsychopharmacology 40(5) , 1203-15, (2015) During the early postnatal period, environmental influences play a pivotal role in shaping the development of the neocortex, including the prefrontal cortex (PFC) that is crucial for working memory an... |
Synonyms
| 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-, hydrochloride (1:1) |
| N-Butyl-N-ethyl-7-mesityl-2,5,6-trimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride (1:1) |
| N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine,hydrochloride |
