Introduction：Basic information about CAS 271780-64-4|LY 393558, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | LY 393558 |
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| CAS Number | 271780-64-4 | Molecular Weight | 546.67700 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C26H31FN4O4S2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 1-[2-[4-(6-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-6-methylsulfonyl-3-propan-2-yl-4H-2λ6,1,3-benzothiadiazine 2,2-dioxide |
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LY 393558 BiologicalActivity
| Description | LY393558 is a potent and orally active inhibitor of the 5-HT transporter and an antagonist of 5-HT1B and 5-HT1D receptors. LY393558 increase the extracellular levels of 5-HT in mice model frontal cortex. LY393558 can be used for researching depression[1]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
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| In Vivo | LY393558 (1-20 mg/kg; p.o., single) raises extracellular levels of 5-HT to 200-250% at 1 mg/kg in guinea pigs model, while levels of 5-HT to approximately 1500% at the highest dose 20 mg/kg[1]. LY393558 (20 mg/kg; p.o., single) completely abolishes the reduction of levels of 5-HT induced by tetrodotoxin (1μM) in guinea pigs model[1]. LY393558 (1-20 mg/kg; p.o., single) significantly increases extracellular levels of 5-HT in rats model[1]. LY393558 (5 mg/kg/day; p.o., 21 days) can still elicit a further increase in extracellular 5-HT in chronic treatment[1]. Animal Model: Female Dunkin Hartley guinea pigs (350-400 g)[1] Dosage: 1-20 mg/kg Administration: p.o., single Result: Extracellular levels of 5-HT reached 200-250% at 1 mg/kg, while levels of 5-HT reached approximately 1500% at the highest dose 20 mg/kg. Animal Model: Female Dunkin Hartley guinea pigs (350-400 g)[1] Dosage: 20 mg/kg Administration: p.o., single Result: Completely abolished the reduction of levels of 5-HT induced by tetrodotoxin (1μM). Animal Model: Male Lister Hooded rats (290-320 g)[1] Dosage: 1-20 mg/kg Administration: p.o., single Result: Significantly increased extracellular levels of 5-HT. Animal Model: Male Lister Hooded rats (290-320 g)[1] Dosage: 5 mg/kg/day Administration: p.o., 21 days Result: Still elicited a further increase in extracellular 5-HT in chronic treatment. |
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| References | [1]. Mitchell SN, et al. LY393558, a 5-hydroxytryptamine reuptake inhibitor and 5-HT(1B/1D) receptor antagonist: effects on extracellular levels of 5-hydroxytryptamine in the guinea pig and rat. Eur J Pharmacol. 2001;432(1):19-27. |
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Chemical & Physical Properties
| Molecular Formula | C26H31FN4O4S2 |
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| Molecular Weight | 546.67700 |
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| Exact Mass | 546.17700 |
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| PSA | 110.55000 |
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| LogP | 5.87740 |
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| InChIKey | QUSLYAPLTMMCFE-UHFFFAOYSA-N |
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| SMILES | CC(C)N1Cc2cc(S(C)(=O)=O)ccc2N(CCN2CC=C(c3c[nH]c4cc(F)ccc34)CC2)S1(=O)=O |
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