CAS 29331-92-8|Licarbazepine
Introduction：Basic information about CAS 29331-92-8|Licarbazepine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Licarbazepine | ||
|---|---|---|---|
| CAS Number | 29331-92-8 | Molecular Weight | 254.28400 |
| Density | 1.336g/cm3 | Boiling Point | 431.3ºC at 760mmHg |
| Molecular Formula | C15H14N2O2 | Melting Point | 186-189ºC |
| MSDS | Chinese | Flash Point | 214.6ºC |
| Symbol | GHS02, GHS07 | Signal Word | Danger |
Names
| Name | Licarbazepine |
|---|---|
| Synonym | More Synonyms |
Licarbazepine BiologicalActivity
| Description | Licarbazepine (BIA 2-005; GP 47779) is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>Neurological Disease |
| Target | Sodium Channel[1] |
| In Vivo | Eslicarbazepine acetate (ESL) is an oral pro-drug that is rapidly and extensively metabolized by the liver via a hydrolytic first-pass metabolism into S-Licarbazepine, the biologically active drug. The plasma level of the prodrug remains below quantification[1]. ESL is a potent antiepileptic agent with a spectrum of action essentially limited to partial-onset and generalized tonic-clonic seizures. Its main mechanism of action is by blocking the voltage-gated sodium channel. ESL works by blocking the voltage-gated sodium channel, which play an essential role in the generation and propagation of the epileptic discharge. ESL is well absorbed after oral administration with a bio-availability about 16% higher than that observed after an equivalent dose of Oxcarbazepine (OXC)[1]. |
| References | [1]. Rajinder P Singh, et al. A review of eslicarbazepine acetate for the adjunctive treatment of partial-onset epilepsy. J Cent Nerv Syst Dis. 2011 Jul 20;3:179-87. |
Chemical & Physical Properties
| Density | 1.336g/cm3 |
|---|---|
| Boiling Point | 431.3ºC at 760mmHg |
| Melting Point | 186-189ºC |
| Molecular Formula | C15H14N2O2 |
| Molecular Weight | 254.28400 |
| Flash Point | 214.6ºC |
| Exact Mass | 254.10600 |
| PSA | 66.56000 |
| LogP | 3.25820 |
| Vapour Pressure | 3.33E-08mmHg at 25°C |
| Index of Refraction | 1.677 |
| InChIKey | BMPDWHIDQYTSHX-UHFFFAOYSA-N |
| SMILES | NC(=O)N1c2ccccc2CC(O)c2ccccc21 |
| Storage condition | Store at RT |
Safety Information
| Symbol | GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H302 + H332-H319 |
| Precautionary Statements | P210-P305 + P351 + P338 |
| Hazard Codes | N,Xn,F |
| Risk Phrases | 51/53-36-20/21/22-11 |
| Safety Phrases | 61-36/37-26-16 |
| RIDADR | UN 3077 9 / PGIII |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles2
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| Evaluation of the matrix effect of different sample matrices for 33 pharmaceuticals by post-column infusion. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1000 , 84-94, (2015) Matrix effects that occur during quantitative measurement by liquid chromatography mass spectrometry specifically when using electrospray ionization are a widely recognized phenomenon. Sample matrix c... |
Synonyms
| 10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide,Licarbazepine |
| Licarbazepine,10,11-Dihydro-10-hydroxy-5H-dibenz(Z)[b,f]azepin-5-carboxamide |
| 10,11-Dihydro-10-hydroxy Carbamazepine |
| 10,11-Dihydro-10-hydroxycarbamazepine |
| 5H-Dibenz[b,f]azepine-5-carboxamide,10,11-dihydro-10-hydroxy- |
