Introduction：Basic information about CAS 353231-17-1|LY-487379, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | LY-487379 |
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| CAS Number | 353231-17-1 | Molecular Weight | 452.44700 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C21H19F3N2O4S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 2,2,2-trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(pyridin-3-ylmethyl)ethanesulfonamide |
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| Synonym | More Synonyms |
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LY-487379 BiologicalActivity
| Description | LY487379 is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 potentiates glutamate-stimulated [35S]GTPγS binding with EC50 values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research[2]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>mGluRResearch Areas >>Neurological Disease |
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| In Vivo | LY487379 (intraperitoneal injection; 30 mg/kg; injected 30 min before the test) requires significantly fewer trials to criterion during the ED phase of the ASST in attentional set-shifting task in male Sprague-Dawley rats. But there has no significant drug effect during any other discrimination stage[1]. LY487379 hydrochloride (intraperitoneal injection; 10-30 mg/kg) induces an increase in microdialysate norepinephrine levels; the dose-effect resembled a bell-shape relationship increased. And it dose-dependently increases extracellular serotonin levels in the medial prefrontal cortex in male Sprague-Dawley rats[1]. |
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| References | [1]. Nikiforuk A, et al. Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats. J Pharmacol Exp Ther. 2010;335(3):665-673. [2]. Schaffhauser H, et al. Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2. Mol Pharmacol. 2003;64(4):798-810. |
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Chemical & Physical Properties
| Molecular Formula | C21H19F3N2O4S |
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| Molecular Weight | 452.44700 |
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| Exact Mass | 452.10200 |
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| PSA | 77.11000 |
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| LogP | 5.86200 |
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| InChIKey | ALMACYDZFBMGOR-UHFFFAOYSA-N |
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| SMILES | COc1ccccc1Oc1ccc(N(Cc2cccnc2)S(=O)(=O)CC(F)(F)F)cc1 |
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Safety Information
Customs
| HS Code | 2935009090 |
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| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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Synonyms
