CAS 35607-20-6|CP-20961
| Common Name | CP-20961 | ||
|---|---|---|---|
| CAS Number | 35607-20-6 | Molecular Weight | 667.18700 |
| Density | 0.892g/cm3 | Boiling Point | 717.6ºC at 760mmHg |
| Molecular Formula | C43H90N2O2 | Melting Point | / |
| MSDS | USA | Flash Point | 294.3ºC |
Names
| Name | 2-[3-(dioctadecylamino)propyl-(2-hydroxyethyl)amino]ethanol |
|---|---|
| Synonym | More Synonyms |
CP-20961 BiologicalActivity
| Description | CP-20961 is a potent synthetic non-immunogenic adjuvant that induces arthritis[1][2]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
| In Vivo | Avridine-induced arthritis is severe and long lasting in LEW and DA rats[2]. CP-20961 (10 mg/kg, i.v., once either 24, 48, or 72 hours post-burn) had no effect on survival after challenge with P. aeruginosa 96 hours post-burn[3]. Animal Model: Female, Hartley-derived guinea pigs, weighing 350 to 400 g[3]. Dosage: 10 mg/kg. Administration: IV once either 24, 48, or 72 hours post-burn. Result: Had no effect on survival after challenge with P. aeruginosa 96 hours post-burn. |
| References | [1]. Brun JG, et al. Effects of calprotectin in avridine-induced arthritis. APMIS. 1995 Mar;103(3):233-40. [2]. Vingsbo C, et al. Avridine-induced arthritis in rats; a T cell-dependent chronic disease influenced both by MHC genes and by non-MHC genes. Clin Exp Immunol. 1995 Mar;99(3):359-63. [3]. Stinnett JD, et al. Synthetic immunomodulators for prevention of fatal infections in a burned guinea pig model. Ann Surg. 1983 Jul;198(1):53-7. |
Chemical & Physical Properties
| Density | 0.892g/cm3 |
|---|---|
| Boiling Point | 717.6ºC at 760mmHg |
| Molecular Formula | C43H90N2O2 |
| Molecular Weight | 667.18700 |
| Flash Point | 294.3ºC |
| Exact Mass | 666.70000 |
| PSA | 46.94000 |
| LogP | 12.48810 |
| Index of Refraction | 1.478 |
| InChIKey | WXNRAKRZUCLRBP-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)CCCN(CCO)CCO |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 3,498,1973
Safety Information
| RIDADR | NONH for all modes of transport |
|---|---|
| RTECS | KK7243000 |
| HS Code | 2922199090 |
Customs
| HS Code | 2922199090 |
|---|---|
| Summary | 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles24
More Articles| Identification of arthritogenic adjuvants of self and foreign origin. Scand. J. Immunol. 49(1) , 45-50, (1999) The lack of defined triggers for human inflammatory joint diseases warrants efforts to identify candidate molecules. For this task, it may be an important lead that nonspecific activation of the immun... | |
| A 71-kD heat shock protein (hsp) from Mycobacterium tuberculosis has modulatory effects on experimental rat arthritis. Clin. Exp. Immunol. 103(1) , 77-82, (1996) The effects of a mycobacterial 71-kD hsp antigen have been investigated for its ability to modulate arthritis in rats. Subcutaneous injection (base of tail) of increasing amounts of hsp71 from Mycobac... | |
| Effect of the bacillus of Calmette-Guérin, Propionibacter acnes and avridine as immunomodulators in antirabies vaccination of mice using the Fuenzalida-Palacios mouse brain vaccine. Vaccine 17(19) , 2446-52, (1999) Using the laboratory mice, Fuenzalida-Palacios mouse brain human rabies vaccine was administered in groups of animals previously inoculated with rabies virus and then submitted to treatments with the ... |
Synonyms
| cp-20,961 |
| avridine |
