CAS 691007-09-7|Risperidone E-oxime

Introduction：Basic information about CAS 691007-09-7|Risperidone E-oxime, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Risperidone E-oxime BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Risperidone E-oxime
CAS Number	691007-09-7	Molecular Weight	430.491
Density	1.3±0.1 g/cm3	Boiling Point	569.0±60.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₈F₂N₄O₂	Melting Point	/
MSDS	/	Flash Point	297.9±32.9 °C

Names

Name	3-[2-[4-[(E)-C-(2,4-difluorophenyl)-N-hydroxycarbonimidoyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
Synonym	More Synonyms

Risperidone E-oxime BiologicalActivity

Description	Risperidone E-oxime is an impurity of Risperidone[1]. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively [2][3].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
References	[1]. Pavel Slanina, et al. Process for making risperidone and intermediates therefor. US20040097523A1. [2]. Nyberg S, et al. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl). 1993;110(3):265-72. [3]. Zhu HJ, et al. Risperidone and paliperidone inhibit p-glycoprotein activity in vitro. Neuropsychopharmacology. 2007 Apr;32(4):757-64.

Description

Risperidone E-oxime is an impurity of Risperidone[1]. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively [2][3].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease

References

[1]. Pavel Slanina, et al. Process for making risperidone and intermediates therefor. US20040097523A1.

[2]. Nyberg S, et al. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl). 1993;110(3):265-72.

[3]. Zhu HJ, et al. Risperidone and paliperidone inhibit p-glycoprotein activity in vitro. Neuropsychopharmacology. 2007 Apr;32(4):757-64.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	569.0±60.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₈F₂N₄O₂
Molecular Weight	430.491
Flash Point	297.9±32.9 °C
Exact Mass	430.218048
PSA	79.68000
LogP	3.16
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.631
InChIKey	BRCINVRBDDVLDW-UHFFFAOYSA-N
SMILES	Cc1nc2n(c(=O)c1CCN1CCC(C(=NO)c3ccc(F)cc3F)CC1)CCCC2
Storage condition	2-8℃

Synonyms

4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-[(E)-(2,4-difluorophenyl)(hydroxyimino)methyl]-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-

3-(2-{4-[(E)-(2,4-Difluorophenyl)(hydroxyimino)methyl]-1-piperidinyl}ethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

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