Introduction：Basic information about CAS 111790-37-5|Biotin-EDA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Biotin-EDA |
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| CAS Number | 111790-37-5 | Molecular Weight | 354.425 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 844.9±65.0 °C at 760 mmHg |
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| Molecular Formula | C12H22N4O2S | Melting Point | 172-174ºC |
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| MSDS | ChineseUSA | Flash Point | 464.8±34.3 °C |
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Names
| Name | 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-(2-aminoethyl)pentanamide |
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| Synonym | More Synonyms |
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Biotin-EDA BiologicalActivity
| Description | Biotin-EDA is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Alkyl-Chain |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 844.9±65.0 °C at 760 mmHg |
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| Melting Point | 172-174ºC |
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| Molecular Formula | C12H22N4O2S |
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| Molecular Weight | 354.425 |
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| Flash Point | 464.8±34.3 °C |
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| Exact Mass | 354.136169 |
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| PSA | 141.70000 |
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| LogP | -0.77 |
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| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
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| Index of Refraction | 1.612 |
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| InChIKey | BNCJEZWKLUBUBB-QXEWZRGKSA-N |
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| SMILES | NCCNC(=O)CCCCC1SCC2NC(=O)NC21 |
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Synonyms
| biotinylethylenediamine |
| BAEA |
| N-Biotinyl-ethylenediamine |
| biotin ethylenediamine |
| 1H-Thieno(3,4-d)imidazole-4-pentanamide,N-(2-aminoethyl)hexahydro-3-oxo-,(3aS,4S,6aR) |
| N-[2-(D-biotinylamino)ethyl]amine |
| N-(2-aminoethyl)biotinamide |
| N-aminoethylaminobiotin |
| [3aS-(3a|A,4|A,6a|A)]-N-(2-Aminoethyl)hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide |
| (3aS,4S,6aR)-N-(2-Aminoethyl)hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide |
| Spiro[3H-azonine-3,4'-[4H]thieno[3,4-d]imidazole]-9-carboxamide, N-ethyltetradecahydro-2,2',8-trioxo-, (3S,3a'S,6a'R)- |
| Biotinylamidoethylacetamide |
| (3S,3a'S,6a'R)-N-Ethyl-2,2',8-trioxohexahydrospiro[azonane-3,4'-thieno[3,4-d]imidazole]-9-carboxamide |
| N-biotinyl-1,2-diaminoethane |
