Introduction：Basic information about CAS 912849-73-1|Azido-PEG10-amine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Azido-PEG10-amine |
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| CAS Number | 912849-73-1 | Molecular Weight | 526.62100 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C22H46N4O10 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | / |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine |
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| Synonym | More Synonyms |
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Azido-PEG10-amine BiologicalActivity
| Description | Azido-PEG10-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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Chemical & Physical Properties
| Molecular Formula | C22H46N4O10 |
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| Molecular Weight | 526.62100 |
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| Exact Mass | 526.32100 |
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| PSA | 168.07000 |
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| LogP | 0.57446 |
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| InChIKey | RMNAJNJBCBFOKX-UHFFFAOYSA-N |
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| SMILES | [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN |
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| Storage condition | 2-8°C |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H315-H319-H335 |
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| Precautionary Statements | P261-P305 + P351 + P338 |
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| Personal Protective Equipment | Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
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| Hazard Codes | Xi |
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| Risk Phrases | 36/37/38 |
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| Safety Phrases | 26 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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Synonyms
| O-(2-Aminoethyl)-O'-(2-azidoethyl)nonaethylene glycol |
| Azido-PEG-amine (n=10) |
| 32-Azido-3,6,9,12,15,18,21,24,27,30-decaoxadotriacontan-1-amine |
| O-(2-Aminoethyl)-O inverted exclamation marka-(2-azidoethyl)nonaethylene glycol |
| Azido-PEG10-amine |
