CAS 24526-64-5|Nomifensine

Introduction：Basic information about CAS 24526-64-5|Nomifensine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Nomifensine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Nomifensine
CAS Number	24526-64-5	Molecular Weight	238.327
Density	1.1±0.1 g/cm3	Boiling Point	378.4±42.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₈N₂	Melting Point	179-181°
MSDS	/	Flash Point	164.0±23.0 °C

Names

Name	nomifensine
Synonym	More Synonyms

Nomifensine BiologicalActivity

Description	Nomifensine is a norepinephrine-dopamine reuptake inhibitor, increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	378.4±42.0 °C at 760 mmHg
Melting Point	179-181°
Molecular Formula	C₁₆H₁₈N₂
Molecular Weight	238.327
Flash Point	164.0±23.0 °C
Exact Mass	238.147003
PSA	29.26000
LogP	2.15
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.623
InChIKey	XXPANQJNYNUNES-UHFFFAOYSA-N
SMILES	CN1Cc2c(N)cccc2C(c2ccccc2)C1
Storage condition	2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX4912700

CHEMICAL NAME :: Isoquinoline, 1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-

CAS REGISTRY NUMBER :: 24526-64-5

LAST UPDATED :: 199512

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H18-N2

MOLECULAR WEIGHT :: 238.36

WISWESSER LINE NOTATION :: T66 CNT&J C1 ER& JZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 7 mg/kg/7D-I

TOXIC EFFECTS :: Blood - hemorrhage Blood - thrombocytopenia

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 288,830,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 6,247,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - aggression

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,873,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 128 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JNPHAG Journal de Pharmacologie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1970- Volume(issue)/page/year: 17,37,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 264 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

REFERENCE :: DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 18,1,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4 mg/kg

SEX/DURATION :: lactating female 1 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

REFERENCE :: GOBIDS Gynecologic and Obstetric Investigation. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.9- 1978- Volume(issue)/page/year: 23,103,1987

Safety Information

Hazard Codes	Xn: Harmful;
Risk Phrases	22-36/37/38
Safety Phrases	26-36
RIDADR	UN 3249
WGK Germany	3
RTECS	NX4912800
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933499090

Customs

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine

1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamin

Merital

Nomifensine

R/S-nomifensine

Nomiphensine

Nomifenison

Nomifensine Maleate

(±)-Nomifensine

alival

Nomifensin

linamiphen

8-Isoquinolinamine,1,2,3,4-tetrahydro-2-methyl-4-phenyl

D,L-nomifensine

1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-isoquinolin

8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-

8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline

8-amino-4-phenyl-2-methyl-1,2,3,4-tetrahydro-isoquinoline

8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline

Psicronizer

2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine

Hostalival

UNII:1LGS5JRP31

2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine

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