Introduction：Basic information about CAS 102036-29-3|Protosappanin B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Protosappanin B |
|---|
| CAS Number | 102036-29-3 | Molecular Weight | 304.29 |
|---|
| Density | 1.5±0.1 g/cm3 | Boiling Point | 655.5±55.0 °C at 760 mmHg |
|---|
| Molecular Formula | C16H16O6 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 350.2±31.5 °C |
|---|
Names
| Name | Protosappanin B |
|---|
| Synonym | More Synonyms |
|---|
Protosappanin B BiologicalActivity
| Description | Protosappanin B is a phenolic compound extracted from Lignum Sappan. Anti-cancer activity[1]. Protosappanin B induces apoptosis and causes G1 cell cycle arrest in human bladder cancer cells[2]. |
|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
|---|
| Target | Apoptosis[2] |
|---|
| In Vitro | Protosappanin B (12.5, 25, 50, 100, 200 µg/mL, 48 hours) dose-dependently inhibits tumor cells, with IC50s of 21.32 µg/mL, 26.73 µg/mL, and 76.53 µg/mL for SW-480, HCT-116, and BTT cells, respectively[1]. Cell Viability Assay[1] Cell Line: CT-116, SW-480, and BTT Cells Concentration: 12.5, 25, 50, 100, 200 µg/mL Incubation Time: 48 hours Result: Dose-dependently inhibited tumor cells after 48 hours of treatment. |
|---|
| References | [1]. Yang X, et al. Antitumor Effects of Purified Protosappanin B Extracted From Lignum Sappan. Integr Cancer Ther. 2016 Mar;15(1):87-95. [2]. Yang X, et al. Protosappanin B promotes apoptosis and causes G1 cell cycle arrest in human bladder cancer cells. Sci Rep. 2019 Jan 31;9(1):1048. |
|---|
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|
| Boiling Point | 655.5±55.0 °C at 760 mmHg |
|---|
| Molecular Formula | C16H16O6 |
|---|
| Molecular Weight | 304.29 |
|---|
| Flash Point | 350.2±31.5 °C |
|---|
| Exact Mass | 304.094696 |
|---|
| PSA | 110.38000 |
|---|
| LogP | 1.13 |
|---|
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
|---|
| Index of Refraction | 1.700 |
|---|
| InChIKey | QRTYTQTVJQUCEP-UHFFFAOYSA-N |
|---|
| SMILES | OCC1(O)COc2cc(O)ccc2-c2cc(O)c(O)cc2C1 |
|---|
| Storage condition | 2~8℃ |
|---|
Safety Information
Synonyms
| (7S)-7-(Hydroxymethyl)-7,8-dihydro-6H-dibenzo[b,d]oxocine-3,7,10,11-tetrol |
| 6H-Dibenz[b,d]oxocin-3,7,10,11-tetrol, 7,8-dihydro-7-(hydroxymethyl)-, (7S)- |
