Introduction：Basic information about CAS 51938-32-0|Schaftoside, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Schaftoside |
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| CAS Number | 51938-32-0 | Molecular Weight | 564.49 |
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| Density | 1.8±0.1 g/cm3 | Boiling Point | 1028.2±65.0 °C at 760 mmHg |
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| Molecular Formula | C26H28O14 | Melting Point | 228ºC |
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| MSDS | ChineseUSA | Flash Point | 342.7±27.8 °C |
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Names
| Name | schaftoside |
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| Synonym | More Synonyms |
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Schaftoside BiologicalActivity
| Description | Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission[1]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Toll-like Receptor (TLR)Signaling Pathways >>Immunology/Inflammation >>MyD88Research Areas >>Inflammation/ImmunologySignaling Pathways >>Metabolic Enzyme/Protease >>Mitochondrial MetabolismSignaling Pathways >>Cytoskeleton >>Dynamin |
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| In Vitro | Schaftoside inhibits three pro-inflammatory enzymatic activities: secretory phospholipase A2 (sPLA2), lipoxygenase (LOX), and cyclooxygenase 2 (COX-2). Schaftoside also inhibits mRNA and protein expressions of proinflammatory cytokines(IL-1β, TNF-α, and IL-6)[1]. |
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| References | [1]. Zhou K, et al. Schaftoside ameliorates oxygen glucose deprivation-induced inflammation associated with the TLR4/Myd88/Drp1-related mitochondrial fission in BV2 microglia cells. J Pharmacol Sci. 2019 Jan;139(1):15-22. |
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Chemical & Physical Properties
| Density | 1.8±0.1 g/cm3 |
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| Boiling Point | 1028.2±65.0 °C at 760 mmHg |
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| Melting Point | 228ºC |
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| Molecular Formula | C26H28O14 |
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| Molecular Weight | 564.49 |
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| Flash Point | 342.7±27.8 °C |
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| Exact Mass | 596.137756 |
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| PSA | 269.43000 |
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| LogP | -3.06 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.754 |
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| InChIKey | MMDUKUSNQNWVET-VYUBKLCTSA-N |
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| SMILES | O=c1cc(-c2ccc(O)cc2)oc2c(C3OCC(O)C(O)C3O)c(O)c(C3OC(CO)C(O)C(O)C3O)c(O)c12 |
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| Storage condition | 2-8°C |
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Safety Information
| Safety Phrases | 24/25 |
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| RIDADR | NONH for all modes of transport |
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| RTECS | DJ2977250 |
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| HS Code | 29389090 |
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Synonyms
| 4H-1-Benzopyran-4-one, 8-(D-arabinopyranosyloxy)-6-(D-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)- |
| Shaftoside |
| Apigenin 8-C-|A-L-arabinoside 6-C-|A-D-glucoside |
| Schaftoside |
| 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-8-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]chromen-4-one |
| 8-(D-Arabinopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-6-yl D-glucopyranoside |
| schaftozide |
