CAS 37239-47-7|Wilforgine

Introduction：Basic information about CAS 37239-47-7|Wilforgine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Wilforgine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Synonyms

Common Name	Wilforgine
CAS Number	37239-47-7	Molecular Weight	857.807
Density	1.4±0.1 g/cm3	Boiling Point	859.9±65.0 °C at 760 mmHg
Molecular Formula	C₄₁H₄₇NO₁₉	Melting Point	211℃
MSDS	/	Flash Point	473.8±34.3 °C

Names

Name	8α-acetoxy-O2-(furan-3-carbonyl)-O2-deacetyl-8-deoxo-evonimine
Synonym	More Synonyms

Wilforgine BiologicalActivity

Description	Wilforgine is a bioactive sesquiterpene alkaloid in Tripterygium wilfordii Hook. F. Wilforgine can induce microstructural and ultrastructural changes in the muscles of Mythimna separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system[1][2].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Ouyang XK, et al. Simultaneous determination of four sesquiterpene alkaloids in Tripterygium wilfordii Hook. F. extracts by high-performance liquid chromatography. Phytochem Anal. 2007 Jul-Aug;18(4):320-5. [2]. Ma S, et al. Comparative studies on muscle microstructure and ultrastructure of Mythimna separata Walker treated with wilforgine and chlorantraniliprole. Ecotoxicol Environ Saf. 2018 Jan;147:1023-1034. [3]. Gao X, et al. Wilforine, the Q-marker and PK-maker of Tripterygium glycosides tablet: Based on preparation quantitative analysis and PK-PD study. Phytomedicine. 2019 Feb 15;54:357-364.

Description

Wilforgine is a bioactive sesquiterpene alkaloid in Tripterygium wilfordii Hook. F. Wilforgine can induce microstructural and ultrastructural changes in the muscles of Mythimna separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system[1][2].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. Ouyang XK, et al. Simultaneous determination of four sesquiterpene alkaloids in Tripterygium wilfordii Hook. F. extracts by high-performance liquid chromatography. Phytochem Anal. 2007 Jul-Aug;18(4):320-5.

[2]. Ma S, et al. Comparative studies on muscle microstructure and ultrastructure of Mythimna separata Walker treated with wilforgine and chlorantraniliprole. Ecotoxicol Environ Saf. 2018 Jan;147:1023-1034.

[3]. Gao X, et al. Wilforine, the Q-marker and PK-maker of Tripterygium glycosides tablet: Based on preparation quantitative analysis and PK-PD study. Phytomedicine. 2019 Feb 15;54:357-364.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	859.9±65.0 °C at 760 mmHg
Melting Point	211℃
Molecular Formula	C₄₁H₄₇NO₁₉
Molecular Weight	857.807
Flash Point	473.8±34.3 °C
Exact Mass	857.274231
PSA	265.89000
LogP	5.32
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.583
InChIKey	QFIYSPKZWOALMZ-VESOVIEISA-N
SMILES	CC(=O)OCC12C(OC(C)=O)C(OC(C)=O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1CCC(C)C(=O)OC(C(OC(=O)c1ccoc1)C2OC(C)=O)C4(C)O
Storage condition	2-8C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LF0195500

CHEMICAL NAME :: Evonimine, 8-(acetyloxy)-O(sup 2)-deacetyl-8-deoxo-O(sup 2)-(3-furanylcarbonyl)-, (8-alpha)-

CAS REGISTRY NUMBER :: 37239-47-7

BEILSTEIN REFERENCE NO. :: 0078231

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C41-H47-N-O19

MOLECULAR WEIGHT :: 857.89

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 474 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 25,266,1990

Synonyms

(1S,3R,15S,18S,19R,20R,21R,22S,23R,24R,25R,26S)-20,22,23,25-Tetraacetoxy-21-(acetoxymethyl)-26-hydroxy-3,15,26-trimethyl-6,16-dioxo-2,5,17-trioxa-11-azapentacyclo[16.7.1.0.0.0]hexaco sa-7,9,11-trien-19-yl 3-furoate

Wilforgine

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