Introduction：Basic information about CAS 22573-93-9|alexidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | alexidine |
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| CAS Number | 22573-93-9 | Molecular Weight | 581.712 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 574.5±60.0 °C at 760 mmHg |
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| Molecular Formula | C26H58Cl2N10 | Melting Point | 220-224ºC |
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| MSDS | / | Flash Point | 301.3±32.9 °C |
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Names
| Name | alexidine |
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| Synonym | More Synonyms |
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alexidine BiologicalActivity
| Description | Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis[1]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>Fungal |
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| In Vitro | With the treatment of Alexidine (10 µM, 24 hours), biofilm community can be decimated[1]. .With the treatment of Alexidine (0-60 μg/ml, 24 hours), Alexidine can kill HUVECs and lung A549 cells[1]. Cell Viability Assay Cell Line: C. albicans, C. auris, A. fumigatus[1] Concentration: 10 µM Incubation Time: 24 hours Result: Could significantly kill 80% of mature biofilm community. Cell Viability Assay Cell Line: HUVECs, lung A549 cells[1] Concentration: 0-60 μg/ml Incubation Time: 24 hours Result: resulted in 50% killing of HUVECs and lung A549 cells ( CC50 > 7.37 μg/ml ). |
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| In Vivo | With the treatment of Alexidine (Jugular vein-catheterized, 48 hours, 3 µg/ml, once) for 48 hours, Alexidine can decimate preformed biofilms growing in the jugular vein catheters of mice[1]. Animal Model: 8-week-old C57BL/6 male mice Dosage: 3 µg/ml Administration: Jugular vein-catheterized, 48 hours, 3 µg/ml, once Result: Inhibited 67% of fungal biofilm growth and viability, compared to the control untreated biofilms. |
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| References | [1]. Zeinab Mamouei, et al. Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens. mSphere. 2018 Oct 31;3(5):e00539-18. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 574.5±60.0 °C at 760 mmHg |
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| Melting Point | 220-224ºC |
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| Molecular Formula | C26H58Cl2N10 |
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| Molecular Weight | 581.712 |
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| Flash Point | 301.3±32.9 °C |
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| Exact Mass | 580.422302 |
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| PSA | 167.58000 |
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| LogP | 4.56 |
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| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
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| Index of Refraction | 1.551 |
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| InChIKey | LFVVNPBBFUSSHL-UHFFFAOYSA-N |
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| SMILES | CCCCC(CC)CN=C(N)NC(N)=NCCCCCCN=C(N)NC(N)=NCC(CC)CCCC |
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| Storage condition | 2-8℃ |
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Safety Information
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | 36/37/38 |
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| Safety Phrases | 26-36 |
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| HS Code | 29224995 |
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Synonyms
| Imidodicarbonimidic diamide, N,N''''-1,6-hexanediylbis[N'-(2-ethylhexyl)-, hydrochloride (1:2) |
| 1,1'-Hexamethylene-bis[5-(2-ethylhexyl)biguanide] dihydrochloride |
| N,N''''-1,6-Hexanediylbis[N'-(2-ethylhexyl)(imidodicarbonimidic diamide)] |
| Sterwin 904 |
| UNII:I2A7616PY1 |
| alexidine 2HCl |
| 1,1'-Hexamethylene-bis(5-[2-ethylhexyl]biguanide) |
| Bisguanidine |
| Prestwick_42 |
| N,N''''-1,6-Hexanediylbis[N'-(2-ethylhexyl)(imidodicarbonimidic diamide)] dihydrochloride |
| n,n''''-hexane-1,6-diylbis[n'-(2-ethylhexyl)(imidodicarbonimidic diamide)] dihydrochloride |
| Alexidine dihydrochloride |
| Bisguadine |
| Imidodicarbonimidic diamide, N,N''''-1,6-hexanediylbis[N'-(2-ethylhexyl)- |
| N,N''''-Hexane-1,6-diylbis[N'-(2-ethylhexyl)(imidodicarbonimidic diamide)] |
| Alexidine.2HCl |
| alexidine |
| QR-711 |
| 1,1'-HEXAMETHYLENE-BIS[5-(2-ETHYLHEXYL)BIGUANIDE] |
| Compound-904 |
