Introduction：Basic information about CAS 328-38-1|H-D-Leu-OH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1].
Related Catalog
Research Areas >>Neurological Disease
Target
Human Endogenous Metabolite
In Vitro
In a screen of candidate neuronal receptors, D-leucine failed to compete for binding by cognate ligands, potentially suggesting a novel target. Even at low doses, D-leucine suppressed ongoing seizures at least as effectively as diazepam but without sedative effects. These studies raise the possibility that D-leucine may represent a new class of anti-seizure agents, and that D-leucine may have a previously unknown function in eukaryotes[1].
References
[1]. Xiaoyu Cao, et al. Combination of PARP Inhibitor and Temozolomide to Suppress Chordoma Progression. J Mol Med (Berl). 2019 Aug;97(8):1183-1193
Chemical & Physical Properties
Density
1.0±0.1 g/cm3
Boiling Point
225.8±23.0 °C at 760 mmHg
Melting Point
> 300ºC
Molecular Formula
C6H13NO2
Molecular Weight
131.173
Flash Point
90.3±22.6 °C
Exact Mass
131.094635
PSA
63.32000
LogP
0.73
Vapour Pressure
0.0±0.9 mmHg at 25°C
Index of Refraction
1.463
InChIKey
ROHFNLRQFUQHCH-RXMQYKEDSA-N
SMILES
CC(C)CC(N)C(=O)O
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
OH2840000
CHEMICAL NAME :
Leucine, D-
CAS REGISTRY NUMBER :
328-38-1
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C6-H13-N-O2
MOLECULAR WEIGHT :
131.20
WISWESSER LINE NOTATION :
QVYZ1Y1&1 -D
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6429 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%
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