Introduction：Basic information about CAS 480-79-5|Integerrimine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Integerrimine |
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| CAS Number | 480-79-5 | Molecular Weight | 335.39500 |
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| Density | 1.25g/cm3 | Boiling Point | 563.7ºC at 760 mmHg |
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| Molecular Formula | C18H25NO5 | Melting Point | 172 °C |
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| MSDS | / | Flash Point | 294.7ºC |
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Names
| Name | Pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl(1,6)dioxacyclododecino(2,3,4-gh) |
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| Synonym | More Synonyms |
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Integerrimine BiologicalActivity
| Description | (-)-Integerrimine, a pyrrolizidine alkaloid, has antiulcerogenic activity. (-)-Integerrimine is also a mutagenic and weakly clastogenic agent in Drosophila[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| In Vitro | (-)-Integerrimine (0.00625-0.05 mM) also must have mutagenic activity in somatic cells of Drosophila. (-)-Integerrimine in general requires cytochrome P450-dependent metabolic activation to exhibit genotoxic activity[1]. |
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| References | [1]. V R Campesato, et al. Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid from Senecio brasiliensis, in somatic cells of Drosophila melanogaster. Environ Mol Mutagen. 1997;29(1):91-7. [2]. Walber Toma, et al. Modulation of gastrin and epidermal growth factor by pyrrolizidine alkaloids obtained from Senecio brasiliensis in acute and chronic induced gastric ulcers. Can J Physiol Pharmacol. 2004 May;82(5):319-25. |
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Chemical & Physical Properties
| Density | 1.25g/cm3 |
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| Boiling Point | 563.7ºC at 760 mmHg |
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| Melting Point | 172 °C |
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| Molecular Formula | C18H25NO5 |
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| Molecular Weight | 335.39500 |
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| Flash Point | 294.7ºC |
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| Exact Mass | 335.17300 |
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| PSA | 76.07000 |
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| LogP | 1.13070 |
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| Vapour Pressure | 4.68E-15mmHg at 25°C |
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| Index of Refraction | 1.57 |
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| InChIKey | HKODIGSRFALUTA-IKZAEVNJSA-N |
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| SMILES | CC=C1CC(C)C(C)(O)C(=O)OCC2=CCN3CCC(OC1=O)C23 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NM9080000
- CHEMICAL NAME :
- Integerrimine
- CAS REGISTRY NUMBER :
- 480-79-5
- LAST UPDATED :
- 199603
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C18-H25-N-O5
- MOLECULAR WEIGHT :
- 335.44
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 78 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg/20D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 18750 ug/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,297,1990
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Safety Information
| Hazard Codes | Xi |
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| RIDADR | UN 1544 |
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| Packaging Group | III |
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| Hazard Class | 6.1(b) |
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Synonyms
| Intergerrimine |
| senecionyne |
| Squalidine |
| INTEGERRIMINE |
| seneciionine |
| 12-hydroxy-senecionane-11,16-dione |
