CAS 29400-42-8|Helvolic acid

Introduction：Basic information about CAS 29400-42-8|Helvolic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Helvolic acid BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	Helvolic acid
CAS Number	29400-42-8	Molecular Weight	568.69800
Density	1.2g/cm3	Boiling Point	675.9ºC at 760 mmHg
Molecular Formula	C₃₃H₄₄O₈	Melting Point	/
MSDS	/	Flash Point	209ºC

Names

Name	helvolic acid
Synonym	More Synonyms

Helvolic acid BiologicalActivity

Description	Helvolic acid (Fumigacin) is an antibiotic isolated from Xylaria sp, active against the Gram-positive bacteria[1].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial
References	[1]. Ratnaweera PB, et al. Helvolic acid, an antibacterial nortriterpenoid from a fungal endophyte, Xylaria sp. of orchid Anoectochilus setaceus endemic to Sri Lanka. Mycology. 2014 Mar;5(1):23-28. Epub 2014 Mar 25.

Chemical & Physical Properties

Density	1.2g/cm3
Boiling Point	675.9ºC at 760 mmHg
Molecular Formula	C₃₃H₄₄O₈
Molecular Weight	568.69800
Flash Point	209ºC
Exact Mass	568.30400
PSA	124.04000
LogP	5.40010
Vapour Pressure	5.01E-20mmHg at 25°C
Index of Refraction	1.556
InChIKey	MDFZYGLOIJNNRM-OAJDADRGSA-N
SMILES	CC(=O)OC1CC2(C)C(CCC3C4(C)C=CC(=O)C(C)C4C(OC(C)=O)C(=O)C32C)C1=C(CCC=C(C)C)C(=O)O

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RC1370000

CHEMICAL NAME :: 29-Nordammara-1,17(20),24-trien-21-oic acid, 6,16-bis(acetyloxy)-3,7-dioxo-, (4-alpha, 6-beta,8-alpha,9-beta,13-alpha,14-beta,16-beta,17-bet a)-

CAS REGISTRY NUMBER :: 29400-42-8

BEILSTEIN REFERENCE NO. :: 3230584

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C33-H44-O8

MOLECULAR WEIGHT :: 568.77

WISWESSER LINE NOTATION :: L E5 B666 FY LV OV PUTJ A1 FUYVQ3UY1&1 GOV1 I1 J1 KOV1 N1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,1837,1978

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,1837,1978

Safety Information

RTECS	RC1370000

Synonyms

hervolic acid

helvol acid

Helvolsaeure

Helvolic acid

Fumigacin

(2Z)-2-[(4S,5S,6S,8S,9S,10R,13R,14S,16S)-6,16-diacetyloxy-4,8,10,14-tetramethyl-3,7-dioxo-5,6,9,11,12,13,15,16-octahydro-4H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid

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