CAS 623-43-8|Methyl (2E)-2-butenoate

Introduction：Basic information about CAS 623-43-8|Methyl (2E)-2-butenoate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles3
7. Synonyms

Common Name	Methyl (2E)-2-butenoate
CAS Number	623-43-8	Molecular Weight	100.116
Density	0.9±0.1 g/cm3	Boiling Point	121.0±0.0 °C at 760 mmHg
Molecular Formula	C₅H₈O₂	Melting Point	/
MSDS	ChineseUSA	Flash Point	4.4±0.0 °C
Symbol	GHS02, GHS07	Signal Word	Danger

Names

Name	trans-Methyl crotonate
Synonym	More Synonyms

Chemical & Physical Properties

Density	0.9±0.1 g/cm3
Boiling Point	121.0±0.0 °C at 760 mmHg
Molecular Formula	C₅H₈O₂
Molecular Weight	100.116
Flash Point	4.4±0.0 °C
Exact Mass	100.052429
PSA	26.30000
LogP	1.32
Vapour Pressure	14.9±0.2 mmHg at 25°C
Index of Refraction	1.414
InChIKey	MCVVUJPXSBQTRZ-ONEGZZNKSA-N
SMILES	CC=CC(=O)OC
Water Solubility	IMMISCIBLE

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GQ5710000

CHEMICAL NAME :: Crotonic acid, methyl ester, (E)-

CAS REGISTRY NUMBER :: 623-43-8

BEILSTEIN REFERENCE NO. :: 1720292

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C5-H8-O2

MOLECULAR WEIGHT :: 100.13

WISWESSER LINE NOTATION :: 2U1VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >19000 ppm/6H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 10 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979

Safety Information

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H315-H319-H335
Precautionary Statements	P210-P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	F:Flammable;Xi:Irritant;
Risk Phrases	R11;R36/37/38
Safety Phrases	S16-S26-S36-S33-S9
RIDADR	UN 3272 3/PG 2
WGK Germany	2
RTECS	GQ5710000
Packaging Group	II
Hazard Class	3.0
HS Code	29161980

Customs

HS Code	2916190090
Summary	2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Articles3

First total syntheses of the phytotoxins solanapyrones D and E via the domino Michael protocol.

J. Org. Chem. 67(17) , 5969-76, (2002)

The phytotoxins solanapyrones D (1) and E (2) have been synthesized from the decalone prepared by the domino Michael reaction of the kinetic enolate of optically pure acetylcyclohexene with methyl cro...

The vinylogous aldol reaction of unsaturated esters and enolizable aldehydes using the novel Lewis acid aluminum tris(2,6-di-2-naphthylphenoxide).

Org. Lett. 14(11) , 2678-81, (2012)

The synthesis of the novel Lewis acid, aluminum tris(2,6-di-2-naphthylphenoxide) (ATNP), and its use in the vinylogous aldol reaction between methyl crotonate and enolizable aldehydes are described. A...

Solvent engineering: an effective tool to direct chemoselectivity in a lipase-catalyzed Michael addition. Priego J, et al.

Tetrahedron 65(2) , 536-539, (2009)

Synonyms

Methyl-(2E)-but-2-enoat

methyl-trans-3-triethylsilylacrylate

methyl trans-crotonate

Crotonic acid, methyl ester

EINECS 210-793-7

Methyl (2E)-but-2-enoate

Methyl Crotonate

methyl-trans-4-oxo-2-pentoate

E-1-triethylsilylpropensaeuremethylester

2-Butenoic acid, methyl ester

crotonic acid methyl ester

2-Butenoic acid, methyl ester, (2E)-

Methyl (2E)-2-butenoate

Crotonic acid, methyl ester (8CI)

MFCD00009287

3-methyl-acrylic acid,methyl ester

Recommended......