Introduction：Basic information about CAS 32738-09-3|5-methyl-2-thiouridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
5-Methyl-2-thiouridine (2-Thio-5-methyluridine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
Signaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/AnalogResearch Areas >>Others
References
[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
Chemical & Physical Properties
Density
1.63g/cm3
Melting Point
216-219 °C
Molecular Formula
C10H14N2O5S
Molecular Weight
274.29
Exact Mass
274.06200
PSA
140.06000
Index of Refraction
1.703
InChIKey
SNNBPMAXGYBMHM-JXOAFFINSA-N
SMILES
Cc1cn(C2OC(CO)C(O)C2O)c(=S)[nH]c1=O
Safety Information
RIDADR
NONH for all modes of transport
WGK Germany
3
HS Code
2934999090
Customs
HS Code
2934999090
Summary
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles11
More Articles
Molecular mechanism of codon recognition by tRNA species with modified uridine in the first position of the anticodon.
Proc. Natl. Acad. Sci. U. S. A. 82 , 4905-4909, (1985)
Proton NMR analyses have been made to elucidate the conformational characteristics of modified nucleotides as found in the first position of the anticodon of tRNA [derivatives of 5-methyl-2-thiouridin...
CD spectra of 5-methyl-2-thiouridine in tRNA-Met-f from an extreme thermophile.
Nucleic Acids Res. 3 , 1703-1713, (1976)
5-Methyl-2-thiouridine (S) in tRNA-Met-f from an extreme thermophile is located in the TpsiC region, replacing T, and has a positive CD band centered at 310 nm. Upon heating, the profiles of the chang...
Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidines.
Nucleic Acids Res. 33 , 5297-5307, (2005)
Substitution of oxygen atoms by sulfur at various locations in the nucleic acid framework has led to analogs such as the DNA phosphorothioates and 4'-thio RNA. The phosphorothioates are excellent mimi...
