Introduction：Basic information about CAS 30413-84-4|Corydalmine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Corydalmine |
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| CAS Number | 30413-84-4 | Molecular Weight | 341.401 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 501.2±50.0 °C at 760 mmHg |
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| Molecular Formula | C20H23NO4 | Melting Point | 177-178℃ |
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| MSDS | / | Flash Point | 256.9±30.1 °C |
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Names
| Name | (13aS)-2,3,9-Trimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2 -a]isoquinolin-10-ol |
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| Synonym | More Synonyms |
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Corydalmine BiologicalActivity
| Description | Corydalmine (L-Corydalmine), an alkaloid isolated from roots of Corydalis Chaerophylla, inhibits spore germination of some plant pathogenic as well as saprophytic fungi[1]. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity[2]. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway[3]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>FungalSignaling Pathways >>GPCR/G Protein >>CXCRSignaling Pathways >>Immunology/Inflammation >>CXCRResearch Areas >>Neurological Disease |
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| Target | CXCR2 |
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| In Vivo | Corydalmine (L-Corydalmine) is a potent analgesic agent, in cynomolgus monkey, beagle dog, rat and mouse liver microsomes[2]. |
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| References | [1]. S Ameer Basha, et al. Effect of 1-corydalmine, an Alkaloid Isolated From Corydalis Chaerophylla Roots on Spore Germination of Some Fungi. Mycobiology. 2007 Jun;35(2):69-71. [2]. Xiange Tang, et al. In Vitro Metabolism of L-Corydalmine, a Potent Analgesic Drug, in Human, Cynomolgus Monkey, Beagle Dog, Rat and Mouse Liver Microsomes. J Pharm Biomed Anal. 2016 Sep 5;128:98-105. [3]. Lin Zhou, et al. Levo-corydalmine Alleviates Vincristine-Induced Neuropathic Pain in Mice by Inhibiting an NF-kappa B-dependent CXCL1/CXCR2 Signaling Pathway. Neuropharmacology. 2018 Jun;135:34-47. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 501.2±50.0 °C at 760 mmHg |
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| Melting Point | 177-178℃ |
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| Molecular Formula | C20H23NO4 |
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| Molecular Weight | 341.401 |
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| Flash Point | 256.9±30.1 °C |
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| Exact Mass | 341.162720 |
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| PSA | 51.16000 |
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| LogP | 2.93 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.640 |
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| InChIKey | DIHXHTWYVOYYDC-INIZCTEOSA-N |
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| SMILES | COc1cc2c(cc1OC)C1Cc3ccc(O)c(OC)c3CN1CC2 |
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Safety Information
Synonyms
| 6H-Dibenzo[a,g]quinolizin-10-ol, 5,8,13,13a-tetrahydro-2,3,9-trimethoxy-, (13aS)- |
| 6H-Dibenzo(a,g)quinolizin-10-ol, 5,8,13,13a-tetrahydro-2,3,9-trimethoxy-, (S)- |
| (13aS)-2,3,9-Trimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinolin-10-ol |
