CAS 957486-82-7|Azido-PEG6-amine
Introduction：Basic information about CAS 957486-82-7|Azido-PEG6-amine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Azido-PEG6-amine | ||
|---|---|---|---|
| CAS Number | 957486-82-7 | Molecular Weight | 350.41100 |
| Density | / | Boiling Point | / |
| Molecular Formula | C14H30N4O6 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine |
|---|---|
| Synonym | More Synonyms |
Azido-PEG6-amine BiologicalActivity
| Description | Azido-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-amine is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
| Target | PEGs Non-cleavable |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References | [1]. Williams EGL, et al. Glycosylated Reversible Addition-Fragmentation Chain Transfer Polymers with Varying Polyethylene Glycol Linkers Produce Different Short Interfering RNA Uptake, Gene Silencing, and Toxicity Profiles. Biomacromolecules. 2017 Dec 11;18(12):4099-4112. [2]. Philip Wilson Howard, et al. Pyrrolobenzodiazepines and conjugates thereof. WO2014140862A2. |
Chemical & Physical Properties
| Molecular Formula | C14H30N4O6 |
|---|---|
| Molecular Weight | 350.41100 |
| Exact Mass | 350.21700 |
| PSA | 131.15000 |
| LogP | 0.50806 |
| InChIKey | VCQSTKKJKNUQBI-UHFFFAOYSA-N |
| SMILES | [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCN |
| Storage condition | 2-8℃ |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xn |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2929909090 |
Customs
| HS Code | 2929909090 |
|---|---|
| Summary | 2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
Synonyms
| AmbotzPEG1087 |
| NH2-PEG7-N3 |
| 20-azido-3,6,9,12,15,18-hexaoxaeicosan-1-amine |
