Introduction：Basic information about CAS 53101-49-8|(R)-Trolox, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
(R)-Trolox is a water soluble vitamin E analogue and a competitive tyrosinase inhibitor with a Ki value of 0.83 mM and a ID50 value of 1.88 mM[1]. The (R)-Trolox has stronger tyrosinase affinity than the (S) enantiomer (Ki value of 0.61 mM)[1].
Related Catalog
Research Areas >>CancerSignaling Pathways >>Metabolic Enzyme/Protease >>Tyrosinase
In Vitro
As compared to the control containing no inhibitor, DMSO suppresses the tyrosinase activity at tested levels, 100 and 200 µL in a total volume of 3.0 mL. The inhibition of DMSO on the mushroom tyrosinase is dosedependent. Additions of DMSO at the two levels in the tyrosinase digests containing (R)-Trolox ((R)-HTCCA) results in further inhibitions of the tyrosinase activity. The influence of the DMSO on the inhibitory effects of (R)-Trolox against the tyrosinase is also dose-dependent[1].
References
[1]. Yu L. Inhibitory effects of (S)- and (R)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acids on tyrosinase activity. J Agric Food Chem. 2003 Apr 9;51(8):2344-7.
Chemical & Physical Properties
Density
1.219g/cm3
Boiling Point
450.3ºC at 760 mmHg
Melting Point
162ºC (dec.)(lit.)
Molecular Formula
C14H18O4
Molecular Weight
250.29000
Flash Point
171ºC
Exact Mass
250.12100
PSA
66.76000
LogP
2.48570
Index of Refraction
1.567
Safety Information
Symbol
GHS07
Signal Word
Warning
Hazard Statements
H315-H319-H335
Precautionary Statements
P261-P305 + P351 + P338
Personal Protective Equipment
dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes
Xi
Risk Phrases
36/37/38
Safety Phrases
26-37/39
RIDADR
NONH for all modes of transport
HS Code
2932999099
Customs
HS Code
2932999099
Summary
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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