CAS 7416-34-4|Molindone

Introduction：Basic information about CAS 7416-34-4|Molindone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Molindone BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	Molindone
CAS Number	7416-34-4	Molecular Weight	276.37400
Density	1.14 g/cm3	Boiling Point	462.9ºC at 760 mmHg
Molecular Formula	C₁₆H₂₄N₂O₂	Melting Point	180 - 181ºC
MSDS	/	Flash Point	233.7ºC

Names

Name	3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one
Synonym	More Synonyms

Molindone BiologicalActivity

Description	Molindone ((±)-Molindone), an indole derivative, is a potent dopamine D2 and D5 receptor antagonist. Molindone ((±)-Molindone) can be used for the research of schizophrenia and severe mental illness[1][2].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease
References	[1]. Krishna G, et al. In vitro and in vivo genotoxicity assessment of the dopamine receptor antagonist molindone hydrochloride. Environ Mol Mutagen. 2016;57(4):288-298. [2]. Bagnall A, et al. Molindone for schizophrenia and severe mental illness. Cochrane Database Syst Rev. 2007;(1):CD002083. Published 2007 Jan 24.

Description

Molindone ((±)-Molindone), an indole derivative, is a potent dopamine D2 and D5 receptor antagonist. Molindone ((±)-Molindone) can be used for the research of schizophrenia and severe mental illness[1][2].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease

References

[1]. Krishna G, et al. In vitro and in vivo genotoxicity assessment of the dopamine receptor antagonist molindone hydrochloride. Environ Mol Mutagen. 2016;57(4):288-298.

[2]. Bagnall A, et al. Molindone for schizophrenia and severe mental illness. Cochrane Database Syst Rev. 2007;(1):CD002083. Published 2007 Jan 24.

Chemical & Physical Properties

Density	1.14 g/cm3
Boiling Point	462.9ºC at 760 mmHg
Melting Point	180 - 181ºC
Molecular Formula	C₁₆H₂₄N₂O₂
Molecular Weight	276.37400
Flash Point	233.7ºC
Exact Mass	276.18400
PSA	45.33000
LogP	1.90070
Index of Refraction	1.559
InChIKey	KLPWJLBORRMFGK-UHFFFAOYSA-N
SMILES	CCc1c(C)[nH]c2c1C(=O)C(CN1CCOCC1)CC2
Water Solubility	H2O: 19 mg/mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM3300000

CHEMICAL NAME :: Indol-4(5H)-one, 3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)-

CAS REGISTRY NUMBER :: 7416-34-4

LAST UPDATED :: 199801

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C16-H24-N2-O2

MOLECULAR WEIGHT :: 276.42

WISWESSER LINE NOTATION :: T56 BM FV&TJ C1 D2 G1- AT6N DOTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 714 ug/kg/D

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - antipsychotic

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,402,1969

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 4285 ug/kg/3D-I

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press, Inc., POB 240008, Memphis, TN 38124) V.39- 1978- Volume(issue)/page/year: 47,607,1986

Safety Information

Hazard Codes	Xn: Harmful;
Risk Phrases	22
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	NM3325000

Synonyms

3-ethyl-2-methyl-5-morpholin-4-ylmethyl-1,5,6,7-tetrahydro-indol-4-one

MOLINDONE

molidone hydrochloride

EN-1733A

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