Introduction：Basic information about CAS 280782-97-0|Managlinat dialanetil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Managlinat dialanetil |
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| CAS Number | 280782-97-0 | Molecular Weight | 500.549 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 634.8±65.0 °C at 760 mmHg |
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| Molecular Formula | C21H33N4O5PS | Melting Point | / |
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| MSDS | / | Flash Point | 337.7±34.3 °C |
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Names
| Name | 2-amino-4-{2-[5-(N,N'-bis((R,S)-1-(1-ethoxycoarbonyl)ethyl)phosphonamido)]furanyl}-5-isobutylthiazole |
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| Synonym | More Synonyms |
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Managlinat dialanetil BiologicalActivity
| Description | Managlinat dialanetil (MB06322) is an orally bioavailable inhibitor of fructose 1,6-bisphosphatase (FBPase) for the treatment of type 2 diabetes[1] [2]. |
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| Related Catalog | Signaling Pathways >>Others >>Others |
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| Target | FBPase[1][2] |
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| In Vivo | Managlinat dialanetil dose-dependently inhibits GNG as well as lower basal and postprandial blood glucose levels in Zucker diabetic fatty (ZDF) rats after oral administration[1]. |
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| References | [1]. Wang Y, et al. Managlinat dialanetil, a fructose-1,6-bisphosphatase inhibitor for the treatment of type 2 diabetes. Curr Opin Investig Drugs. 2007 Oct;8(10):849-58. [2]. Wang Y, et al. Managlinat dialanetil, a fructose-1,6-bisphosphatase inhibitor for the treatment of type 2 diabetes. Curr Opin Investig Drugs. 2007 Oct;8(10):849-58. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 634.8±65.0 °C at 760 mmHg |
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| Molecular Formula | C21H33N4O5PS |
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| Molecular Weight | 500.549 |
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| Flash Point | 337.7±34.3 °C |
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| Exact Mass | 500.185852 |
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| PSA | 183.83000 |
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| LogP | 2.57 |
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| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
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| Index of Refraction | 1.552 |
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| InChIKey | JGCMEVUWRCNKKE-KBPBESRZSA-N |
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| SMILES | CCOC(=O)C(C)NP(NC(C)C(=O)OCC)c1ccc(-c2nc(N)sc2CC(C)C)o1 |
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Safety Information
Synonyms
| MANAGLINAT DIALANETIL/CS-917 |
| ethyl (2S,6S)-4-{5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}-2,6-dimethyl-7-oxo-8-oxa-3,5-diaza-4-phosphadecan-1-oate 4-oxide (non-preferred name) |
| ethyl 4-[5-(2-amino-5-isobutyl-1,3-thiazol-4-yl)-2-furyl]-2,6-dimethyl-7-oxo-8-oxa-3,5-d iaza-4-phosphadecan-1-oate 4-oxide |
| Ethyl (2S,6S)-4-[5-(2-amino-5-isobutyl-1,3-thiazol-4-yl)-2-furyl]-2,6-dimethyl-7-oxo-8-oxa-3,5-diaza-4-phosphadecan-1-oate 4-oxide |
| Managlinat dialanetil |
| managlinat dialantenil |
