CAS 816-66-0|Ketoleucine
| Common Name | Ketoleucine | ||
|---|---|---|---|
| CAS Number | 816-66-0 | Molecular Weight | 130.142 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 190.5±9.0 °C at 760 mmHg |
| Molecular Formula | C6H10O3 | Melting Point | 8-10 °C |
| MSDS | ChineseUSA | Flash Point | 83.3±15.2 °C |
| Symbol | GHS05 | Signal Word | Danger |
Names
| Name | 4-methyl-2-oxopentanoic acid |
|---|---|
| Synonym | More Synonyms |
Ketoleucine BiologicalActivity
| Description | 4-Methyl-2-oxopentanoic acid, an abnormal metabolite, is both a neurotoxin and a metabotoxin. |
|---|---|
| Related Catalog | Natural Products >>Acids and AldehydesResearch Areas >>Metabolic DiseaseResearch Areas >>Neurological Disease |
| Target | Human Endogenous Metabolite |
| References | [1]. Yudkoff M, et al. Brain amino acid requirements and toxicity: the example of leucine. J Nutr. 2005 Jun;135(6 Suppl):1531S-8S. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 190.5±9.0 °C at 760 mmHg |
| Melting Point | 8-10 °C |
| Molecular Formula | C6H10O3 |
| Molecular Weight | 130.142 |
| Flash Point | 83.3±15.2 °C |
| Exact Mass | 130.062988 |
| PSA | 54.37000 |
| LogP | 0.17 |
| Vapour Pressure | 0.2±0.8 mmHg at 25°C |
| Index of Refraction | 1.438 |
| InChIKey | BKAJNAXTPSGJCU-UHFFFAOYSA-N |
| SMILES | CC(C)CC(=O)C(=O)O |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS05 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H314 |
| Precautionary Statements | P280-P305 + P351 + P338-P310 |
| Personal Protective Equipment | Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | C:Corrosive; |
| Risk Phrases | R34 |
| Safety Phrases | S26-S36/37/39-S45 |
| RIDADR | UN 3265 8/PG 3 |
| WGK Germany | 3 |
| Packaging Group | III |
| Hazard Class | 8 |
| HS Code | 2918300090 |
Customs
| HS Code | 2918300090 |
|---|---|
| Summary | 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
Articles35
More Articles| Physiology and pathophysiology of organic acids in cerebrospinal fluid. J. Inherit. Metab. Dis. 16(4) , 648-69, (1993) Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo... | |
| The signalling role of action potential depolarization in insulin secretion: metabolism-dependent dissociation between action potential increase and secretion increase by TEA. Biochem. Pharmacol. 80(1) , 104-12, (2010) The K(+) channel blocker, TEA is known to increase action potential amplitude and insulin secretion of mouse beta-cells when added to a nutrient secretagogue. In the presence of a maximally effective ... | |
| Production of α-ketoisocaproate via free-whole-cell biotransformation byRhodococcus opacusDSM 43250 withl-leucine as the substrate Enzyme Microb. Technol. 49(4) , 321-5, (2011) This work aims to produce α-ketoisocaproate (KIC) from l-leucine via the free-whole-cell biotransformation of Rhodococcus opacus DSM 43250. The effects of temperature, pH, substrate concentration, cel... |
Synonyms
| 2-Oxo-4-methylvaleric acid |
| α-ketoisocaproic acid |
| 2-Oxoisocaproic acid |
| 2-KETOISOCAPROIC ACID |
| EINECS 212-435-5 |
| 4-Methyl-2-oxopentanoic acid |
| Pentanoic acid, 4-methyl-2-oxo- |
| &α;-ketoisocaproic acid |
| 2-keto-4-Methylvaleric acid |
| 4-Methyl-2-oxovaleric Acid |
| 4-methyl-2-oxo-Valeric acid |
| Ketoleucine |
| MFCD00066204 |
| α-keto-isocaproic acid |
