Introduction：Basic information about CAS 27653-68-5|Trimethoprim N-oxide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Trimethoprim N-oxide |
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| CAS Number | 27653-68-5 | Molecular Weight | 306.31700 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C14H18N4O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Trimethoprim N-oxide |
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| Synonym | More Synonyms |
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Trimethoprim N-oxide BiologicalActivity
| Description | Trimethoprim N-oxide (Trimethoprim 1-N-oxide) belongs to human urinary metabolites. Trimethoprim N-oxide is generated by oxidation of nitrogen atoms in the pyrimidine ring. Trimethoprim N-oxide is formed predominantly by CYP1A2 in human liver microsomes[1]. |
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| Related Catalog | Research Areas >>Infection |
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| References | [1]. Goldman JL, et al. In Vitro Hepatic Oxidative Biotransformation of Trimethoprim. Drug Metab Dispos. 2015 Sep;43(9):1372-80. |
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Chemical & Physical Properties
| Molecular Formula | C14H18N4O4 |
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| Molecular Weight | 306.31700 |
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| Exact Mass | 306.13300 |
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| PSA | 118.08000 |
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| LogP | 2.45350 |
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| InChIKey | XAYZHNKZSZREPH-UHFFFAOYSA-N |
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| SMILES | COc1cc(Cc2cn(O)c(=N)nc2N)cc(OC)c1OC |
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Synonyms
| 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine 1-oxide |
| 2,4-Pyrimidinediamine, 5-[(3,4,5-trimethoxyphenyl)methyl]-, 1-oxide |
