CAS 29700-22-9|Oxyresveratrol

Introduction：Basic information about CAS 29700-22-9|Oxyresveratrol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Oxyresveratrol BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Oxyresveratrol
CAS Number	29700-22-9	Molecular Weight	244.243
Density	1.5±0.1 g/cm3	Boiling Point	523.8±30.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₂O₄	Melting Point	201ºC
MSDS	/	Flash Point	260.8±19.2 °C

Names

Name	4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol
Synonym	More Synonyms

Oxyresveratrol BiologicalActivity

Description	Oxyresveratrol is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. It effectively scavenges H2O2, NO (IC50 = 45.3 μM), and the artificial free radical 2,2-diphenyl-l-picrylhydrazyl (IC50 = 28.9 μM) In vitro: 1)oxyresveratrol exhibited more than 50% inhibition at 100 μM on L-tyrosine oxidation by murine tyrosinase activity.2) oxyresveratrol showed an IC50 value of 52.7 μM on the enzyme activity. 3) oxyresveratrol works through reversible inhibition of tyrosinase activity rather than suppression of the expression and synthesis of the enzyme.[2] In vivo: 1) Oxyresveratrol (10 or 20 mg/kg) significantly reduced the brain infarct volume by approximately 54% and 63%, respectively, when compared to vehicle-treated MCAO rats.2) oxyresveratrol treatment diminished cytochrome c release and decreasedcaspase-3 activation in MCAO rats. [3]
Related Catalog	Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Metabolic Enzyme/Protease >>TyrosinaseResearch Areas >>OthersNatural Products >>Phenols
References	[1]. Lorenz. et al. Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: Effect on nitrosative and oxidative stress derived from microglial cells. Nitric Oxide 9(2) 64-76 (2003). [2]. Kim, Y.M., Yun, J., Lee, C., et al. Oxyresveratrol and hydroxystilbene compounds. Inhbitory effect on tyrosinase and mechanism of action. J Biol Chem277(18) 16340-16344 (2002). [3]. Shaida A Andrabi et al. Oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. Brain Res, 2004 Aug 13, 1017(1-2):98-107.

Description

Oxyresveratrol is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. It effectively scavenges H2O2, NO (IC50 = 45.3 μM), and the artificial free radical 2,2-diphenyl-l-picrylhydrazyl (IC50 = 28.9 μM) In vitro: 1)oxyresveratrol exhibited more than 50% inhibition at 100 μM on L-tyrosine oxidation by murine tyrosinase activity.2) oxyresveratrol showed an IC50 value of 52.7 μM on the enzyme activity. 3) oxyresveratrol works through reversible inhibition of tyrosinase activity rather than suppression of the expression and synthesis of the enzyme.[2] In vivo: 1) Oxyresveratrol (10 or 20 mg/kg) significantly reduced the brain infarct volume by approximately 54% and 63%, respectively, when compared to vehicle-treated MCAO rats.2) oxyresveratrol treatment diminished cytochrome c release and decreasedcaspase-3 activation in MCAO rats. [3]

Related Catalog

Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Metabolic Enzyme/Protease >>TyrosinaseResearch Areas >>OthersNatural Products >>Phenols

References

[1]. Lorenz. et al. Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: Effect on nitrosative and oxidative stress derived from microglial cells. Nitric Oxide 9(2) 64-76 (2003).

[2]. Kim, Y.M., Yun, J., Lee, C., et al. Oxyresveratrol and hydroxystilbene compounds. Inhbitory effect on tyrosinase and mechanism of action. J Biol Chem277(18) 16340-16344 (2002).

[3]. Shaida A Andrabi et al. Oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. Brain Res, 2004 Aug 13, 1017(1-2):98-107.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	523.8±30.0 °C at 760 mmHg
Melting Point	201ºC
Molecular Formula	C₁₄H₁₂O₄
Molecular Weight	244.243
Flash Point	260.8±19.2 °C
Exact Mass	244.073563
PSA	80.92000
LogP	3.17
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.801
InChIKey	PDHAOJSHSJQANO-OWOJBTEDSA-N
SMILES	Oc1cc(O)cc(C=Cc2ccc(O)cc2O)c1

Safety Information

Hazard Codes	Xi
Risk Phrases	36
Safety Phrases	26

Synonyms

4-[(E)-2-(3,5-Dihydroxyphenyl)ethenyl]benzene-1,3-diol

Puag-haad

2,4,3',5'-Tetrahydroxystilbene

3,4,3',5'-tetrahydroxy-trans-stilbene

OXYLRESVERATROL

trans-oxyresveratrol

2,3',4,5'-Tetrahydroxy-trans-stilbene

(E)-4-(3,5-Dihydroxystyryl)benzene-1,3-diol

Oxyresveratrol

1,3-Benzenediol, 4-(2-(3,5-dihydroxyphenyl)ethenyl)-, (E)-

EINECS 300-008-4

2,3',4,5'-Tetrahydroxystilbene

4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]-1,3-benzenediol

trans-2,3',4,5'-tetrahydroxystilbene

4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]benzene-1,3-diol

1,3-Benzenediol, 4-(2-(3,5-dihydroxyphenyl)ethenyl)-

1,3-Benzenediol, 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]-

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