CAS 84484-78-6|BTS 54-505 hydrochloride

Introduction：Basic information about CAS 84484-78-6|BTS 54-505 hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BTS 54-505 hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	BTS 54-505 hydrochloride
CAS Number	84484-78-6	Molecular Weight	288.26
Density	/	Boiling Point	337.9ºC at 760 mmHg
Molecular Formula	C₁₅H₂₃Cl₂N	Melting Point	160 - 166°C (lit.)
MSDS	/	Flash Point	195.1ºC

Names

Name	1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutan-1-amine,hydrochloride
Synonym	More Synonyms

BTS 54-505 hydrochloride BiologicalActivity

Description	Didesmethylsibutramine (BTS 54-505) hydrochloride is the primary amine metabolite of Sibutramine (antidepressant and anti-obesity agent). Didesmethylsibutramine hydrochloride inhibits NMDA-evoked activity. Didesmethylsibutramine hydrochloride is also a reuptake inhibitor. Didesmethylsibutramine hydrochloride induces thermogenesis[1][2].
Related Catalog	Research Areas >>Metabolic Disease
References	[1]. Liu YL, et al. Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major pharmacologically active metabolite of the novel anti-obesity drug, sibutramine. Int J Obes Relat Metab Disord. 2002 Sep;26(9):1245-53. [2]. Scott G, et al. The effects of BTS 54,505, a metabolite of sibutramine, on monoamine and excitatory amino acid-evoked responses in the rat dorsolateral geniculate nucleus in vivo. Br J Pharmacol. 1994 Jan;111(1):97-102.

Description

Didesmethylsibutramine (BTS 54-505) hydrochloride is the primary amine metabolite of Sibutramine (antidepressant and anti-obesity agent). Didesmethylsibutramine hydrochloride inhibits NMDA-evoked activity. Didesmethylsibutramine hydrochloride is also a reuptake inhibitor. Didesmethylsibutramine hydrochloride induces thermogenesis[1][2].

Related Catalog

Research Areas >>Metabolic Disease

References

[1]. Liu YL, et al. Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major pharmacologically active metabolite of the novel anti-obesity drug, sibutramine. Int J Obes Relat Metab Disord. 2002 Sep;26(9):1245-53.

[2]. Scott G, et al. The effects of BTS 54,505, a metabolite of sibutramine, on monoamine and excitatory amino acid-evoked responses in the rat dorsolateral geniculate nucleus in vivo. Br J Pharmacol. 1994 Jan;111(1):97-102.

Chemical & Physical Properties

Boiling Point	337.9ºC at 760 mmHg
Melting Point	160 - 166°C (lit.)
Molecular Formula	C₁₅H₂₃Cl₂N
Molecular Weight	288.26
Flash Point	195.1ºC
Exact Mass	287.120758
PSA	26.02000
LogP	5.63740
InChIKey	KHRVYINTXCWNRF-UHFFFAOYSA-N
SMILES	CC(C)CC(N)C1(c2ccc(Cl)cc2)CCC1.Cl
Storage condition	Desiccate at RT

Synonyms

MFCD03411585

Didesmethylsibutramine hydrochloride

Bts 54 505

Cyclobutanemethanamine, 1-(4-chlorophenyl)-α-(2-methylpropyl)-, hydrochloride (1:1)

UNII:XJH8PK8XYH

1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutan-1-amine hydrochloride (1:1)

Cyclobutanemethanamine, 1-(4-chlorophenyl)-α-(2-methylpropyl)-, hydrochloride

1-[1-(4-Chlorophenyl)cyclobutyl]-3-methyl-1-butanamine hydrochloride (1:1)

1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride

Recommended......