CAS 147837-52-3|N-Acetyl-Val-Ala-Asp-al
| Common Name | N-Acetyl-Val-Ala-Asp-al | ||
|---|---|---|---|
| CAS Number | 147837-52-3 | Molecular Weight | 329.349 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 698.2±55.0 °C at 760 mmHg |
| Molecular Formula | C14H23N3O6 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 376.0±31.5 °C |
Names
| Name | (3S)-3-[[(2S)-2-[[(2S)-2-acetamido-3-methylbutanoyl]amino]propanoyl]amino]-4-oxobutanoic acid |
|---|---|
| Synonym | More Synonyms |
N-Acetyl-Val-Ala-Asp-al BiologicalActivity
| Description | Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor. Ac-VAD-CHO inhibits dissipation of MMP and cytochrome c release in hypoxia-exposed cells[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Apoptosis >>Caspase |
| References | [1]. Jee-Youn Kim, et al. ROS-dependent caspase-9 activation in hypoxic cell death. FEBS Lett. 2003 Aug 14;549(1-3):94-8. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 698.2±55.0 °C at 760 mmHg |
| Molecular Formula | C14H23N3O6 |
| Molecular Weight | 329.349 |
| Flash Point | 376.0±31.5 °C |
| Exact Mass | 329.158691 |
| PSA | 141.67000 |
| LogP | -0.05 |
| Vapour Pressure | 0.0±4.7 mmHg at 25°C |
| Index of Refraction | 1.498 |
| InChIKey | BGFYQRSQECIBIB-PEXQALLHSA-N |
| SMILES | CC(=O)NC(C(=O)NC(C)C(=O)NC(C=O)CC(=O)O)C(C)C |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles3
More Articles| zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation. Autophagy 7 , 217-228, (2011) The treatment of L929 fibrosarcoma cells with zVAD has been shown to induce necroptosis. However, whether autophagy is involved or not in this event remains controversial. In this study, we re-examine... | |
| Inhibition of human caspases by peptide-based and macromolecular inhibitors. J. Biol. Chem. 273 , 32608-32613, (1998) Studies with peptide-based and macromolecular inhibitors of the caspase family of cysteine proteases have helped to define a central role for these enzymes in inflammation and mammalian apoptosis. A c... | |
| Caspase activation by BCR cross-linking in immature B cells: differential effects on growth arrest and apoptosis. FASEB J. 13 , 931-944, (1999) The B cell lymphoma WEHI-231 has been used as a model to study immature B cell tolerance, based on its capacity to undergo growth arrest and programmed cell death on B cell receptor (BCR) cross-linkin... |
Synonyms
| Ac-VAD-CHO |
| N-acetyl-L-valyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-alaninamide |
| N-Acetyl-Val-Ala-Asp-al |
| L-Alaninamide,N-acetyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-(9CI) |
| L-Alaninamide, N-acetyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]- |
| N-Acetyl-L-valyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-alaninamide |
| Ac-Val-Ala-Asp-CHO |
| L-alaninamide,N-acetyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl] |
| Caspase Inhibitor II |
| L-Alaninamide,N-acetyl-L-valyl-N-(2-carboxy-1-formylethyl)-,(S) |
