Introduction：Basic information about CAS 503-49-1|3-hydroxy-3-methylglutaric acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol.
Related Catalog
Signaling Pathways >>Metabolic Enzyme/Protease >>HMG-CoA Reductase (HMGCR)Research Areas >>Cardiovascular Disease
Chemical & Physical Properties
Density
1.417 g/cm3
Boiling Point
120 °C / 13mmHg
Melting Point
105-108 °C(lit.)
Molecular Formula
C6H10O5
Molecular Weight
162.14100
Flash Point
182.2ºC
Exact Mass
162.05300
PSA
94.83000
Index of Refraction
1.512
InChIKey
NPOAOTPXWNWTSH-UHFFFAOYSA-N
SMILES
CC(O)(CC(=O)O)CC(=O)O
Storage condition
−20°C
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
MA3753000
CHEMICAL NAME :
Glutaric acid, 3-hydroxy-3-methyl-
CAS REGISTRY NUMBER :
503-49-1
BEILSTEIN REFERENCE NO. :
1769194
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C6-H10-O5
MOLECULAR WEIGHT :
162.16
WISWESSER LINE NOTATION :
QV1XQ1&1VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7330 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1284,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3230 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1284,1975
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
Articles27
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NMR Biomed. 19(2) , 271-8, (2006)
A diagnosis of 3-methylglutaconic aciduria type I (OMIM: 250950) based on elevated urinary excretion of 3-methylglutaconic acid (3MGA), 3-methylglutaric acid (3MG) and 3-hydroxyisovaleric acid (3HIVA)...
Unimolecular reaction chemistry of a charge-tagged beta-hydroxyperoxyl radical.
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β-Hydroxyperoxyl radicals are formed during atmospheric oxidation of unsaturated volatile organic compounds such as isoprene. They are intermediates in the combustion of alcohols. In these environment...
Mitochondrial DNA depletion associated with partial complex II and IV deficiencies and 3-methylglutaconic aciduria.
J. Child Neurol. 16(2) , 136-8, (2001)
We report a patient with mitochondrial DNA depletion, partial complex II and IV deficiencies, and 3-methylglutaconic aciduria. Complex II deficiency has not been previously observed in mitochondrial D...
