CAS 50935-71-2|Kirromycin
| Common Name | Kirromycin | ||
|---|---|---|---|
| CAS Number | 50935-71-2 | Molecular Weight | 796.94300 |
| Density | 1.279g/cm3 | Boiling Point | 936ºC at 760 mmHg |
| Molecular Formula | C43H60N2O12 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 519.9ºC |
Names
| Name | Kirromycin |
|---|---|
| Synonym | More Synonyms |
Kirromycin BiologicalActivity
| Description | Kirromycin (Mocimycin) is an antibiotic produced by Streptomyces ramocissimus. Kirromycin is a bacterial protein synthesis inhibitor that immobilizes elongation factor Tu (EF-Tu) on the elongating ribosome[1][2]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
| References | [1]. H Wolf, et al. Kirromycin, an inhibitor of protein biosynthesis that acts on elongation factor Tu. Proc Natl Acad Sci U S A. 1974 Dec;71(12):4910-4. [2]. Lian N Olsthoorn-Tieleman, et al. Elongation factor Tu3 (EF-Tu3) from the kirromycin producer Streptomyces ramocissimus Is resistant to three classes of EF-Tu-specific inhibitors. J Bacteriol. 2007 May;189(9):3581-90. |
Chemical & Physical Properties
| Density | 1.279g/cm3 |
|---|---|
| Boiling Point | 936ºC at 760 mmHg |
| Molecular Formula | C43H60N2O12 |
| Molecular Weight | 796.94300 |
| Flash Point | 519.9ºC |
| Exact Mass | 796.41500 |
| PSA | 228.10000 |
| LogP | 3.46570 |
| Index of Refraction | 1.621 |
| InChIKey | HMSYAPGFKGSXAJ-UHFFFAOYSA-N |
| SMILES | CC=CC=CC1OC(O)(C(CC)C(=O)NCC=CC=C(C)C(OC)C(C)C2OC(C=CC=CC=C(C)C(=O)c3c(O)cc[nH]c3=O)C(O)C2O)C(O)C(O)C1(C)C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,109,1981
Safety Information
| RIDADR | NONH for all modes of transport |
|---|
Articles25
More Articles| A signal relay between ribosomal protein S12 and elongation factor EF-Tu during decoding of mRNA. RNA 15(2) , 208-14, (2009) Codon recognition by aminoacyl-tRNA on the ribosome triggers a process leading to GTP hydrolysis by elongation factor Tu (EF-Tu) and release of aminoacyl-tRNA into the A site of the ribosome. The natu... | |
| The phosphopantetheinyl transferase KirP activates the ACP and PCP domains of the kirromycin NRPS/PKS of Streptomyces collinus Tü 365. FEMS Microbiol. Lett. 319(1) , 26-33, (2011) The main steps in the biosynthesis of complex secondary metabolites such as the antibiotic kirromycin are catalyzed by modular polyketide synthases (PKS) and/or nonribosomal peptide synthetases (NRPS)... | |
| Thermodynamic properties of nucleotide-free EF-Tu from Thermus thermophilus in the presence of low-molecular weight effectors of its GTPase activity. Biochim. Biophys. Acta 1597(1) , 22-7, (2002) The thermal transition of elongation factor EF-Tu from Thermus thermophilus in the presence of low-molecular weight effectors was studied by differential scanning calorimetry. The effectors of GTPase ... |
Synonyms
| antibiotic myc-8003 |
