CAS 76721-89-6|Thiorphan

Introduction：Basic information about CAS 76721-89-6|Thiorphan, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Thiorphan BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles31
7. Synonyms

Common Name	Thiorphan
CAS Number	76721-89-6	Molecular Weight	253.32
Density	1.2±0.1 g/cm3	Boiling Point	524.0±50.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₅NO₃S	Melting Point	138-140ºC
MSDS	ChineseUSA	Flash Point	270.7±30.1 °C

Names

Name	2-[(2-benzyl-3-sulfanylpropanoyl)amino]acetic acid
Synonym	More Synonyms

Thiorphan BiologicalActivity

Description	Thiorphan is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM[1].
Related Catalog	Research Areas >>Neurological DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Neprilysin
References	[1]. Whyteside AR, Turner AJ. Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences. FEBS Lett. 2008 Jul 9;582(16):2382-6.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	524.0±50.0 °C at 760 mmHg
Melting Point	138-140ºC
Molecular Formula	C₁₂H₁₅NO₃S
Molecular Weight	253.32
Flash Point	270.7±30.1 °C
Exact Mass	253.077271
PSA	105.20000
LogP	1.37
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.577
InChIKey	LJJKNPQAGWVLDQ-UHFFFAOYSA-N
SMILES	O=C(O)CNC(=O)C(CS)Cc1ccccc1

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2930909090

Customs

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles31

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1.

J. Pharmacol. Exp. Ther. 346(1) , 31-7, (2013)

The serine protease chymase has been reported to generate intracardiac angiotensin-II (Ang-II) from Ang-I as well as an intermediate precursor of endothelin-1 (ET-1), ET-1 (1-31) from Big-ET-1. Althou...

A comparative study of racecadotril and single dose octreotide as an anti-secretory agent in acute infective diarrhoea.

J. Assoc. Physicians India 60 , 12-5, (2012)

To assess the efficacy of single dose of octreotide and compare it with another antisecretory agent racecadotril in the management of acute infective diarrhea.A randomized control study was done in th...

Synonyms

N-[(RS)-2-Benzyl-3-mercaptopropanoyl]-glycine

DL-[N-(3-mercapto-2-benzylpropanoyl)]glycine

Glycine,N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-,(+-)

N-[(R,S)-3-mercapto-2-benzyl-propionyl]glycine

DL-Thiorphan

Tiorphan

(2-mercaptomethyl-3-phenyl-propionylamino)-acetic acid

Glycine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-, (±)-

Glycine, N-[3-mercapto-1-oxo-2-(phenylmethyl)propyl]-

N-(2-Benzyl-3-sulfanylpropanoyl)glycine

DL-3-Mercapto-2-benzylpropanoylglycine

Prestwick_694

N-(3-mercapto-2-benzylpropanoyl)glycine

(2-MERCAPTOMETHYL-3-PHENYL-PROPIONYL)-GLYCINE

(3-Mercapto-2-benzylpropionyl)glycine

Thiorphan

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