CAS 942142-51-0|VTP-27999

Introduction：Basic information about CAS 942142-51-0|VTP-27999, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. VTP-27999 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	VTP-27999
CAS Number	942142-51-0	Molecular Weight	525.08100
Density	1.178g/cm3	Boiling Point	703.1ºC at 760 mmHg
Molecular Formula	C₂₆H₄₁ClN₄O₅	Melting Point	/
MSDS	/	Flash Point	379ºC

Names

Name	methyl N-[2-[(R)-(3-chlorophenyl)-[(3R)-1-[[(2S)-2-(methylamino)-3-[(3R)-oxan-3-yl]propyl]carbamoyl]piperidin-3-yl]methoxy]ethyl]carbamate
Synonym	More Synonyms

VTP-27999 BiologicalActivity

Description	VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.Ic50 value:Target: Renin
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>ReninResearch Areas >>Cardiovascular Disease
References	[1]. Lanqi Jia et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751 [2]. New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082.

Description

VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.Ic50 value:Target: Renin

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>ReninResearch Areas >>Cardiovascular Disease

References

[1]. Lanqi Jia et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751

[2]. New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082.

Chemical & Physical Properties

Density	1.178g/cm3
Boiling Point	703.1ºC at 760 mmHg
Molecular Formula	C₂₆H₄₁ClN₄O₅
Molecular Weight	525.08100
Flash Point	379ºC
Exact Mass	524.27700
PSA	101.16000
LogP	4.69060
Index of Refraction	1.537
InChIKey	NXWASIVXQMMPLM-ZXMXYHOLSA-N
SMILES	CNC(CNC(=O)N1CCCC(C(OCCNC(=O)OC)c2cccc(Cl)c2)C1)CC1CCCOC1
Storage condition	2-8℃

Synonyms

Methyl (2-{(R)-(3-Chlorophenyl)[(3r)-1-({(2s)-2-(Methylamino)-3-[(3r)-Tetrahydro-2h-Pyran-3-Yl]propyl}carbamoyl)piperidin-3-Yl]methoxy}ethyl)carbamate

Methyl (2-((R)-(3-chlorophenyl)((R)-1-(((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propyl)carbamoyl)piperidin-3-yl)methoxy)ethyl)carbamate

QC-4593

VTP-27999

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