Introduction：Basic information about CAS 100938-10-1|Amastatin · HCl, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Amastatin · HCl |
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| CAS Number | 100938-10-1 | Molecular Weight | 511.009 |
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| Density | / | Boiling Point | 795.1ºC at 760 mmHg |
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| Molecular Formula | C21H39ClN4O8 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 434.7ºC |
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Names
| Name | Amastatin hydrochloride hydrate |
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| Synonym | More Synonyms |
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Amastatin · HCl BiologicalActivity
| Description | Amastatin hydrochloride is a slow, tight binding, competitive aminopeptidase (AP) inhibitor with Ki values of 0.26 nM, 30 nM, 52 nM for Aeromonas aminopeptidase, cytosolic leucine aminopeptidase, microsomal aminopeptidase[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Metabolic Enzyme/Protease >>AminopeptidaseSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Amastatin hydrochloride (1-10000 ng/ml) exhibitcd inhibitory profiles of E. cuniczcli replication in vitro in a dose dependent manner[2]. |
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| References | [1]. S H Wilkes, et al. The Slow, Tight Binding of Bestatin and Amastatin to Aminopeptidases. J Biol Chem. 1985 Oct 25;260(24):13154-62. [2]. J J Millership, et al. In Vitro and in Vivo Evaluation of Aminopeptidase Inhibitors as Antimicrosporidial Therapies. J Eukaryot Microbiol. 2001;Suppl:95S-98S. |
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Chemical & Physical Properties
| Boiling Point | 795.1ºC at 760 mmHg |
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| Molecular Formula | C21H39ClN4O8 |
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| Molecular Weight | 511.009 |
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| Flash Point | 434.7ºC |
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| Exact Mass | 510.245636 |
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| PSA | 208.15000 |
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| LogP | 1.72140 |
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| Vapour Pressure | 3.14E-29mmHg at 25°C |
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| InChIKey | GBDUPCKQTDKNLS-PORDUOSCSA-N |
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| SMILES | CC(C)CC(N)C(O)C(=O)NC(C(=O)NC(C(=O)NC(CC(=O)O)C(=O)O)C(C)C)C(C)C.Cl |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Articles2
More Articles
| Zollner, H. Handbook of Enzyme Inhibitors 2nd ed.,, (1993) 2nd Ed. , 547
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| Beynon, R.J. and Bond, J.S. Proteolytic Enzymes: A Practical Approach New York, NY , (1989), 247
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Synonyms
| amastatin hydrochloride |
| MFCD00150636 |
| Aspartic acid, N-(3-amino-2-hydroxy-5-methyl-1-oxohexyl)valylvalyl-, hydrochloride (1:1) |
| N-(3-Amino-2-hydroxy-5-methylhexanoyl)valylvalylaspartic acid hydrochloride (1:1) |
