Introduction：Basic information about CAS 22733-60-4|NSC 135048, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | NSC 135048 |
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| CAS Number | 22733-60-4 | Molecular Weight | 342.47 |
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| Density | 1.18g/cm3 | Boiling Point | 427.8ºC at 760mmHg |
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| Molecular Formula | C22H30O3 | Melting Point | 139-140° |
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| MSDS | / | Flash Point | 212.5ºC |
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Names
| Name | Siccanin |
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| Synonym | More Synonyms |
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NSC 135048 BiologicalActivity
| Description | Siccanin is a succinate dehydrogenase (SDH) inhibitor (IC50=0.9 μM) with species-selective activity. Siccanin also is a antibiotic against pathogenic fungi[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Fungal |
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| Target | Succinate Dehydrogenase Inhibitor |
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| In Vitro | Siccanin (10 μg/mL) 具有物种选择性，Siccanin 抑制铜绿假单胞菌和恶臭假单胞菌的细菌 SDH，但不抑制大肠杆菌和谷氨酸棒杆菌的 SDH；Siccanin 抑制啮齿动物 SDH 但不抑制猪 SDH[1]。 具体而言，Siccanin 抑制铜绿假单胞菌（残留活性 13%）和恶臭假单胞菌（>1%）膜以及小鼠（>7%）和大鼠（19%）肝线粒体的 SDH，但不抑制大肠杆菌的 SDH (77%) 和谷氨酸棒杆菌 (97%) 膜和猪心脏线粒体 (106%)[1]。 Siccanin (3 μg/mL) 竞争性抑制须癣毛癣菌的生长 (IC50=0.3 μg/mL)[1]。 |
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| References | [1]. Mogi T, et al. Siccanin rediscovered as a species-selective succinate dehydrogenase inhibitor. J Biochem. 2009 Sep;146(3):383-7. |
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Chemical & Physical Properties
| Density | 1.18g/cm3 |
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| Boiling Point | 427.8ºC at 760mmHg |
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| Melting Point | 139-140° |
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| Molecular Formula | C22H30O3 |
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| Molecular Weight | 342.47 |
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| Flash Point | 212.5ºC |
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| Exact Mass | 342.21900 |
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| PSA | 38.69000 |
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| LogP | 5.14570 |
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| Vapour Pressure | 6.41E-08mmHg at 25°C |
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| Index of Refraction | 1.593 |
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| InChIKey | UGGAILYEBCSZIV-AJEXHJJASA-N |
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| SMILES | Cc1cc(O)c2c(c1)OC1(C)CCC3C(C)(C)CCCC34COC2C14 |
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Synonyms
